TY - JOUR
T1 - Apolipoprotein e and LRP1 increase early in Parkinson's disease pathogenesis
AU - Wilhelmus, Micha M.M.
AU - Bol, John G.J.M.
AU - Van Haastert, Elise S.
AU - Rozemuller, Annemieke J.M.
AU - Bu, Guojun
AU - Drukarch, Benjamin
AU - Hoozemans, Jeroen J.M.
PY - 2011/11
Y1 - 2011/11
N2 - Parkinson's disease (PD) is characterized by α-synucleincontaining Lewy bodies (LBs) and loss of melanized neurons in the substantia nigra (SN). Recently, a link between apolipoprotein E (ApoE) expression, α-synuclein aggregation, and neurodegeneration was suggested. Here, we report on ApoE expression appearing in melanized neurons of the SN and in LBs in both PD and incidental LB disease cases. Interestingly, increased expression of the low-density lipoprotein receptor-related protein 1 (the receptor for ApoE) was also observed in incidental LB disease and PD. Our data suggest that alterations in lipoprotein homeostasis/signaling in melanized neurons of the SN are an early event during PD pathogenesis.
AB - Parkinson's disease (PD) is characterized by α-synucleincontaining Lewy bodies (LBs) and loss of melanized neurons in the substantia nigra (SN). Recently, a link between apolipoprotein E (ApoE) expression, α-synuclein aggregation, and neurodegeneration was suggested. Here, we report on ApoE expression appearing in melanized neurons of the SN and in LBs in both PD and incidental LB disease cases. Interestingly, increased expression of the low-density lipoprotein receptor-related protein 1 (the receptor for ApoE) was also observed in incidental LB disease and PD. Our data suggest that alterations in lipoprotein homeostasis/signaling in melanized neurons of the SN are an early event during PD pathogenesis.
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U2 - 10.1016/j.ajpath.2011.07.021
DO - 10.1016/j.ajpath.2011.07.021
M3 - Article
C2 - 21907175
AN - SCOPUS:80055001193
SN - 0002-9440
VL - 179
SP - 2152
EP - 2156
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 5
ER -