Apolipoprotein e and LRP1 increase early in Parkinson's disease pathogenesis

Micha M M Wilhelmus, John G J M Bol, Elise S. Van Haastert, Annemieke J M Rozemuller, Guojun D Bu, Benjamin Drukarch, Jeroen J M Hoozemans

Research output: Contribution to journalArticle

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Abstract

Parkinson's disease (PD) is characterized by α-synucleincontaining Lewy bodies (LBs) and loss of melanized neurons in the substantia nigra (SN). Recently, a link between apolipoprotein E (ApoE) expression, α-synuclein aggregation, and neurodegeneration was suggested. Here, we report on ApoE expression appearing in melanized neurons of the SN and in LBs in both PD and incidental LB disease cases. Interestingly, increased expression of the low-density lipoprotein receptor-related protein 1 (the receptor for ApoE) was also observed in incidental LB disease and PD. Our data suggest that alterations in lipoprotein homeostasis/signaling in melanized neurons of the SN are an early event during PD pathogenesis.

Original languageEnglish (US)
Pages (from-to)2152-2156
Number of pages5
JournalAmerican Journal of Pathology
Volume179
Issue number5
DOIs
StatePublished - Nov 2011

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Apolipoproteins
Parkinson Disease
Substantia Nigra
Low Density Lipoprotein Receptor-Related Protein-1
Lewy Bodies
Lewy Body Disease
Apolipoproteins E
Neurons
Synucleins
Lipoproteins
Homeostasis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Wilhelmus, M. M. M., Bol, J. G. J. M., Van Haastert, E. S., Rozemuller, A. J. M., Bu, G. D., Drukarch, B., & Hoozemans, J. J. M. (2011). Apolipoprotein e and LRP1 increase early in Parkinson's disease pathogenesis. American Journal of Pathology, 179(5), 2152-2156. https://doi.org/10.1016/j.ajpath.2011.07.021

Apolipoprotein e and LRP1 increase early in Parkinson's disease pathogenesis. / Wilhelmus, Micha M M; Bol, John G J M; Van Haastert, Elise S.; Rozemuller, Annemieke J M; Bu, Guojun D; Drukarch, Benjamin; Hoozemans, Jeroen J M.

In: American Journal of Pathology, Vol. 179, No. 5, 11.2011, p. 2152-2156.

Research output: Contribution to journalArticle

Wilhelmus, MMM, Bol, JGJM, Van Haastert, ES, Rozemuller, AJM, Bu, GD, Drukarch, B & Hoozemans, JJM 2011, 'Apolipoprotein e and LRP1 increase early in Parkinson's disease pathogenesis', American Journal of Pathology, vol. 179, no. 5, pp. 2152-2156. https://doi.org/10.1016/j.ajpath.2011.07.021
Wilhelmus MMM, Bol JGJM, Van Haastert ES, Rozemuller AJM, Bu GD, Drukarch B et al. Apolipoprotein e and LRP1 increase early in Parkinson's disease pathogenesis. American Journal of Pathology. 2011 Nov;179(5):2152-2156. https://doi.org/10.1016/j.ajpath.2011.07.021
Wilhelmus, Micha M M ; Bol, John G J M ; Van Haastert, Elise S. ; Rozemuller, Annemieke J M ; Bu, Guojun D ; Drukarch, Benjamin ; Hoozemans, Jeroen J M. / Apolipoprotein e and LRP1 increase early in Parkinson's disease pathogenesis. In: American Journal of Pathology. 2011 ; Vol. 179, No. 5. pp. 2152-2156.
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