Apolipoprotein A-I in Coronary-Artery Disease

Terry J. Pundiak, Boas Gonen, James J. Maciejko, David R. Holmes, Bruce A. Kottke, Alan R. Zinsmeister, Dac M. Dinh, Simon J.T. Mao

Research output: Contribution to journalLetter

Abstract

To the Editor: If apolipoprotein A-I is considered to be a portion of plasma high-density-lipoprotein (HDL) particles, how is it that the plasma levels by weight can be four times higher than HDL levels? Figure 2 in the article by Maciejko et al. (Aug. 18 issue) shows patients with HDL levels in the range of 40 mg per deciliter who simultaneously had apolipoprotein A-I levels in the range of 160 mg per deciliter.* Does this suggest that the major portion of apolipoprotein A-I is found outside HDL particles, or is this an artifact of laboratory-assay units?.

Original languageEnglish (US)
Pages (from-to)123-124
Number of pages2
JournalNew England Journal of Medicine
Volume310
Issue number2
DOIs
StatePublished - Jan 12 1984

ASJC Scopus subject areas

  • Medicine(all)

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    Pundiak, T. J., Gonen, B., Maciejko, J. J., Holmes, D. R., Kottke, B. A., Zinsmeister, A. R., Dinh, D. M., & Mao, S. J. T. (1984). Apolipoprotein A-I in Coronary-Artery Disease. New England Journal of Medicine, 310(2), 123-124. https://doi.org/10.1056/NEJM198401123100214