TY - JOUR
T1 - Aplastic Crisis due to Extensive Bone Marrow Necrosis in Sickle Cell Disease
AU - Pardoll, Drew M.
AU - Rodeheffer, Richard J.
AU - Smith, Robert R.L.
AU - Charache, Samuel
PY - 1982/11
Y1 - 1982/11
N2 - A lengthy aplastic crisis, manifest by pancytopenia and fever, was observed in a young woman with sickle cell β°-thalassemia. Bone marrow aspirates and biopsy specimens showed marrow necrosis, and reticuloendothelial scans showed widespread abnormalities consistent with marrow infarction. Physical damage to erythropoietic tissue as well as arrest of erythropoiesis can cause acute erythroblastopenia in patients with sickle cell anemia.
AB - A lengthy aplastic crisis, manifest by pancytopenia and fever, was observed in a young woman with sickle cell β°-thalassemia. Bone marrow aspirates and biopsy specimens showed marrow necrosis, and reticuloendothelial scans showed widespread abnormalities consistent with marrow infarction. Physical damage to erythropoietic tissue as well as arrest of erythropoiesis can cause acute erythroblastopenia in patients with sickle cell anemia.
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U2 - 10.1001/archinte.1982.00340250189034
DO - 10.1001/archinte.1982.00340250189034
M3 - Article
C2 - 7138173
AN - SCOPUS:0019946177
SN - 0003-9926
VL - 142
SP - 2223
EP - 2225
JO - Archives of internal medicine
JF - Archives of internal medicine
IS - 12
ER -