Aplastic Crisis due to Extensive Bone Marrow Necrosis in Sickle Cell Disease

Drew M. Pardoll, Richard J. Rodeheffer, Robert R.L. Smith, Samuel Charache

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Abstract

A lengthy aplastic crisis, manifest by pancytopenia and fever, was observed in a young woman with sickle cell β°-thalassemia. Bone marrow aspirates and biopsy specimens showed marrow necrosis, and reticuloendothelial scans showed widespread abnormalities consistent with marrow infarction. Physical damage to erythropoietic tissue as well as arrest of erythropoiesis can cause acute erythroblastopenia in patients with sickle cell anemia.

Original languageEnglish (US)
Pages (from-to)2223-2225
Number of pages3
JournalArchives of internal medicine
Volume142
Issue number12
DOIs
StatePublished - Nov 1982

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ASJC Scopus subject areas

  • Internal Medicine

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