Aortic valve replacement in patients with amyloidosis

Amit P. Java, Kevin L. Greason, Angela Dispenzieri, Martha Grogan, Katherine S. King, Joseph Maleszewski, Richard C. Daly, Mackram Eleid, Alberto Pochettino, Hartzell V Schaff

Research output: Contribution to journalArticle

7 Scopus citations


Background: Outcome data on aortic valve replacement in patients with amyloidosis are limited. To address this issue, we reviewed our experience of patients with amyloidosis who underwent aortic valve replacement. Methods: We retrospectively reviewed the records of 16 patients with amyloidosis who underwent aortic valve replacement between May 2000 and February 2017. Results: The cohort comprised 11 males (69%) and 5 females (31%). The median patient age was 76 years (interquartile range [IQR], 71-82 years), and Society of Thoracic Surgeons predicted rate of mortality was 5.0% (IQR, 2.4%-8.7%). Amyloidosis type was immunoglobulin light chain in 6 patients (38%), age-related in 6 (38%), and localized in 4 (25%). The operation was surgical aortic valve replacement in 11 patients (69%) and balloon-expandable transfemoral transcatheter aortic valve insertion in the other 5. There was no procedure-related stroke, need for new-onset dialysis or pacemaker, or death within 30 days of surgery. The median length of hospital stay was 1 day (IQR, 1-2 days) in the transcatheter valve insertion group and 6 days (IQR, 6-8 days) in the surgical group (P = .002). Follow-up was available for all patients at a median of 1.9 years (IQR, 1.2-4.8 years). During the follow-up period, there were 4 deaths, all occurring >1 year after surgery. Conclusions: Aortic valve replacement can be performed with low risk of operative morbidity and mortality in patients with amyloidosis. Transcatheter valve insertion has the advantage of reduced hospital length of stay. The 1-year survival is excellent.

Original languageEnglish (US)
JournalJournal of Thoracic and Cardiovascular Surgery
StateAccepted/In press - Jan 1 2018



  • Amyloid, amyloidosis
  • Aortic valve
  • Aortic valve stenosis
  • Cardiac amyloid
  • Cardiac amyloidosis
  • Surgical aortic valve replacement
  • Transcatheter aortic valve insertion
  • Transcatheter aortic valve replacement

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this