Anxiety affects cognition differently in healthy apolipoprotein E ε4 homozygotes and non-carriers

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9 Citations (Scopus)

Abstract

It is not known whether apolipoprotein E ε4-an Alzheimer disease susceptibility gene-influences the effects of state-anxiety on executive functioning in healthy individuals. In a prospective cohort study of 185 cognitively normal individuals, there were ε4 homozygotes, heterozygotes, and non-carriers, who did not differ in age, sex, years of education, cognitive test scores, psychotropic medications, and state- or trait-anxiety. However, higher anxiety was associated with significantly worse Trails B performance in the ε4 homozygotes, as compared with ε4 non-carriers. The association of executive-functioning difficulties and anxiety appears more likely to occur in persons who are most at risk for subsequent cognitive decline.

Original languageEnglish (US)
Pages (from-to)294-299
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume23
Issue number3
DOIs
StatePublished - 2011

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Apolipoprotein E4
Homozygote
Cognition
Anxiety
Sex Education
Disease Susceptibility
Heterozygote
Alzheimer Disease
Cohort Studies
Prospective Studies
Genes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology

Cite this

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abstract = "It is not known whether apolipoprotein E ε4-an Alzheimer disease susceptibility gene-influences the effects of state-anxiety on executive functioning in healthy individuals. In a prospective cohort study of 185 cognitively normal individuals, there were ε4 homozygotes, heterozygotes, and non-carriers, who did not differ in age, sex, years of education, cognitive test scores, psychotropic medications, and state- or trait-anxiety. However, higher anxiety was associated with significantly worse Trails B performance in the ε4 homozygotes, as compared with ε4 non-carriers. The association of executive-functioning difficulties and anxiety appears more likely to occur in persons who are most at risk for subsequent cognitive decline.",
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