TY - JOUR
T1 - Anxiety affects cognition differently in healthy apolipoprotein E ε4 homozygotes and non-carriers
AU - Stonnington, Cynthia M.
AU - Locke, Dona E.C.
AU - Dueck, Amylou C.
AU - Caselli, Richard J.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - It is not known whether apolipoprotein E ε4-an Alzheimer disease susceptibility gene-influences the effects of state-anxiety on executive functioning in healthy individuals. In a prospective cohort study of 185 cognitively normal individuals, there were ε4 homozygotes, heterozygotes, and non-carriers, who did not differ in age, sex, years of education, cognitive test scores, psychotropic medications, and state- or trait-anxiety. However, higher anxiety was associated with significantly worse Trails B performance in the ε4 homozygotes, as compared with ε4 non-carriers. The association of executive-functioning difficulties and anxiety appears more likely to occur in persons who are most at risk for subsequent cognitive decline.
AB - It is not known whether apolipoprotein E ε4-an Alzheimer disease susceptibility gene-influences the effects of state-anxiety on executive functioning in healthy individuals. In a prospective cohort study of 185 cognitively normal individuals, there were ε4 homozygotes, heterozygotes, and non-carriers, who did not differ in age, sex, years of education, cognitive test scores, psychotropic medications, and state- or trait-anxiety. However, higher anxiety was associated with significantly worse Trails B performance in the ε4 homozygotes, as compared with ε4 non-carriers. The association of executive-functioning difficulties and anxiety appears more likely to occur in persons who are most at risk for subsequent cognitive decline.
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U2 - 10.1176/jnp.23.3.jnp294
DO - 10.1176/jnp.23.3.jnp294
M3 - Article
C2 - 21948890
AN - SCOPUS:80055006017
SN - 0895-0172
VL - 23
SP - 294
EP - 299
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 3
ER -