Antipsychotic Drugs: Prediction of Side-Effect Profiles Based on Neuroreceptor Data Derived From Human Brain Tissue

JOHN L. BLACK; ELLIOTT RICHELSON

doi:10.1016/S0025-6196(12)65440-8

Antipsychotic Drugs: Prediction of Side-Effect Profiles Based on Neuroreceptor Data Derived From Human Brain Tissue

JOHN L. BLACK, ELLIOTT RICHELSON

Neuroscience

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The affinities of antipsychotic agents for neurotransmitter receptors are believed to be responsible for their antipsychotic activity and side-effect profiles. Data on neuroreceptor affinity can be used to predict side-effect profiles of antipsychotic drugs. In this report, we present data on receptor affinity that have been modified to help clinicians clearly see the potential for each drug to produce a specific side effect at any dosage.

Original language	English (US)
Pages (from-to)	369-372
Number of pages	4
Journal	Mayo Clinic proceedings
Volume	62
Issue number	5
DOIs	https://doi.org/10.1016/S0025-6196(12)65440-8
State	Published - 1987

ASJC Scopus subject areas

General Medicine

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10.1016/S0025-6196(12)65440-8

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title = "Antipsychotic Drugs: Prediction of Side-Effect Profiles Based on Neuroreceptor Data Derived From Human Brain Tissue",

abstract = "The affinities of antipsychotic agents for neurotransmitter receptors are believed to be responsible for their antipsychotic activity and side-effect profiles. Data on neuroreceptor affinity can be used to predict side-effect profiles of antipsychotic drugs. In this report, we present data on receptor affinity that have been modified to help clinicians clearly see the potential for each drug to produce a specific side effect at any dosage.",

author = "BLACK, {JOHN L.} and ELLIOTT RICHELSON",

year = "1987",

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AU - RICHELSON, ELLIOTT

PY - 1987

Y1 - 1987

N2 - The affinities of antipsychotic agents for neurotransmitter receptors are believed to be responsible for their antipsychotic activity and side-effect profiles. Data on neuroreceptor affinity can be used to predict side-effect profiles of antipsychotic drugs. In this report, we present data on receptor affinity that have been modified to help clinicians clearly see the potential for each drug to produce a specific side effect at any dosage.

AB - The affinities of antipsychotic agents for neurotransmitter receptors are believed to be responsible for their antipsychotic activity and side-effect profiles. Data on neuroreceptor affinity can be used to predict side-effect profiles of antipsychotic drugs. In this report, we present data on receptor affinity that have been modified to help clinicians clearly see the potential for each drug to produce a specific side effect at any dosage.

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U2 - 10.1016/S0025-6196(12)65440-8

DO - 10.1016/S0025-6196(12)65440-8

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Antipsychotic Drugs: Prediction of Side-Effect Profiles Based on Neuroreceptor Data Derived From Human Brain Tissue

Abstract

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