TY - JOUR
T1 - Antiphospholipid syndrome and the relationship between laboratory assay positivity and prevalence of non-bacterial thrombotic endocarditis
T2 - A retrospective cohort study
AU - Lenz, Charles J.
AU - Mankad, Rekha
AU - Klarich, Kyle
AU - Kurmann, Reto
AU - McBane, Robert D.
N1 - Publisher Copyright:
© 2020 International Society on Thrombosis and Haemostasis
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Background: Nonbacterial thrombotic endocarditis (NBTE) is a potential complication of antiphospholipid syndrome (APS) manifesting as noninfectious lesions on one or more cardiac valves. There are limited tools to inform clinicians regarding which APS patients would benefit most from echocardiographic screening for this complication. Objectives: We tested the hypothesis that the risk of both prevalent and incident NBTE is directly related to the number of positive laboratory assays for APS. Patients/methods: In this single-center, retrospective, cohort study design, consecutive patients with confirmed APS seen at Mayo Clinic Rochester, MN (1/1/1993-6/26/2016), were identified by searching a centralized electronic database. Demographic data, clinical presentation, echocardiographic features, laboratory findings, and survival data were scrutinized. Results: During the study period, 611 patients met the diagnostic criteria for APS and 386 (63%) underwent echocardiography. Of these, 58 (15%) were found to have NBTE. NBTE was more common in those with double (19.4%) and triple-positive laboratory criteria (27.0%) compared with single-positive disease (5.7%, P <.001). Survival free of NBTE diagnosis was significantly shorter in those patients with >1 positive laboratory assay (P <.01). Cox proportional hazard analysis suggests that patients with APS are more likely to be diagnosed with NBTE if they have >1 positive laboratory assay (relative risk 20.1; 95% confidence interval 1.3-316.6; P <.03). Conclusion: Antiphospholipid syndrome carries a high prevalence of NBTE (15%). This prevalence is particularly high for patients with either double- or triple-positive laboratory criteria.
AB - Background: Nonbacterial thrombotic endocarditis (NBTE) is a potential complication of antiphospholipid syndrome (APS) manifesting as noninfectious lesions on one or more cardiac valves. There are limited tools to inform clinicians regarding which APS patients would benefit most from echocardiographic screening for this complication. Objectives: We tested the hypothesis that the risk of both prevalent and incident NBTE is directly related to the number of positive laboratory assays for APS. Patients/methods: In this single-center, retrospective, cohort study design, consecutive patients with confirmed APS seen at Mayo Clinic Rochester, MN (1/1/1993-6/26/2016), were identified by searching a centralized electronic database. Demographic data, clinical presentation, echocardiographic features, laboratory findings, and survival data were scrutinized. Results: During the study period, 611 patients met the diagnostic criteria for APS and 386 (63%) underwent echocardiography. Of these, 58 (15%) were found to have NBTE. NBTE was more common in those with double (19.4%) and triple-positive laboratory criteria (27.0%) compared with single-positive disease (5.7%, P <.001). Survival free of NBTE diagnosis was significantly shorter in those patients with >1 positive laboratory assay (P <.01). Cox proportional hazard analysis suggests that patients with APS are more likely to be diagnosed with NBTE if they have >1 positive laboratory assay (relative risk 20.1; 95% confidence interval 1.3-316.6; P <.03). Conclusion: Antiphospholipid syndrome carries a high prevalence of NBTE (15%). This prevalence is particularly high for patients with either double- or triple-positive laboratory criteria.
KW - Libman-Sacks endocarditis
KW - Marantic endocarditis
KW - antiphospholipid antibody syndrome
KW - lupus anticoagulant
KW - nonbacterial endocarditis
UR - http://www.scopus.com/inward/record.url?scp=85083383569&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083383569&partnerID=8YFLogxK
U2 - 10.1111/jth.14798
DO - 10.1111/jth.14798
M3 - Article
C2 - 32180317
AN - SCOPUS:85083383569
SN - 1538-7933
VL - 18
SP - 1408
EP - 1414
JO - Journal of Thrombosis and Haemostasis
JF - Journal of Thrombosis and Haemostasis
IS - 6
ER -