TY - JOUR
T1 - Antiepileptic drugs 2012
T2 - Recent advances and trends
AU - Sirven, Joseph I.
AU - Noe, Katherine
AU - Hoerth, Matthew
AU - Drazkowski, Joseph
N1 - Funding Information:
Potential Competing Interests: Dr Sirven has received research support from Eisai, Epilepsy Therapy Project, MAP, National Institutes of Health, Neuropace, UCB, Upsher Smith, and Vertex.
PY - 2012/9
Y1 - 2012/9
N2 - There are now 24 antiepileptic drugs (AEDs) approved for use in epilepsy in the United States by the Food and Drug Administration. A literature search was conducted using PubMed, MEDLINE, and Google for all English-language articles that discuss newly approved AEDs and the use of AEDs in epilepsy in the United States from January 1, 2008, through December 31, 2011. Five new agents were identified that have come onto the market within the past 2 years. Moreover, 3 trends involving AEDs have become clinically important and must be considered by all who treat patients with epilepsy. These trends include issues of generic substitution of AEDs, pharmacogenomics predicting serious adverse events in certain ethnic populations, and the issue of the suicide risk involving the entire class of AEDs. This article discusses the most recent AEDs approved for use in the United States and the 3 important trends shaping the modern medical management of epilepsy.
AB - There are now 24 antiepileptic drugs (AEDs) approved for use in epilepsy in the United States by the Food and Drug Administration. A literature search was conducted using PubMed, MEDLINE, and Google for all English-language articles that discuss newly approved AEDs and the use of AEDs in epilepsy in the United States from January 1, 2008, through December 31, 2011. Five new agents were identified that have come onto the market within the past 2 years. Moreover, 3 trends involving AEDs have become clinically important and must be considered by all who treat patients with epilepsy. These trends include issues of generic substitution of AEDs, pharmacogenomics predicting serious adverse events in certain ethnic populations, and the issue of the suicide risk involving the entire class of AEDs. This article discusses the most recent AEDs approved for use in the United States and the 3 important trends shaping the modern medical management of epilepsy.
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U2 - 10.1016/j.mayocp.2012.05.019
DO - 10.1016/j.mayocp.2012.05.019
M3 - Review article
C2 - 22958992
AN - SCOPUS:84866368274
SN - 0025-6196
VL - 87
SP - 879
EP - 889
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 9
ER -