Anti-apoptotic mechanisms of HIV: Lessons and novel approaches to curing HIV

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Past efforts at curing infection with the human immunodeficiency virus (HIV) have been blocked by the resistance of some infected cells to viral cytopathic effects and the associated development of a latent viral reservoir. Furthermore, current efforts to clear the viral reservoir by means of reactivating latent virus are hampered by the lack of cell death in the newly productively infected cells. The purpose of this review is to describe the many anti-apoptotic mechanisms of HIV, as well as the current limitations in the field. Only by understanding how infected cells avoid HIV-induced cell death can an effective strategy to kill infected cells be developed.

Original languageEnglish (US)
Pages (from-to)3355-3363
Number of pages9
JournalCellular and Molecular Life Sciences
Volume70
Issue number18
DOIs
StatePublished - Sep 2013

Fingerprint

HIV
Viral Cytopathogenic Effect
Cell Death
Viruses
Infection

Keywords

  • Apoptosis
  • Human immunodeficiency virus
  • Immune evasion
  • Latency

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Anti-apoptotic mechanisms of HIV : Lessons and novel approaches to curing HIV. / Cummins, Nathan W; Badley, Andrew David.

In: Cellular and Molecular Life Sciences, Vol. 70, No. 18, 09.2013, p. 3355-3363.

Research output: Contribution to journalArticle

@article{71acc34017c743749001f01d4fba61c6,
title = "Anti-apoptotic mechanisms of HIV: Lessons and novel approaches to curing HIV",
abstract = "Past efforts at curing infection with the human immunodeficiency virus (HIV) have been blocked by the resistance of some infected cells to viral cytopathic effects and the associated development of a latent viral reservoir. Furthermore, current efforts to clear the viral reservoir by means of reactivating latent virus are hampered by the lack of cell death in the newly productively infected cells. The purpose of this review is to describe the many anti-apoptotic mechanisms of HIV, as well as the current limitations in the field. Only by understanding how infected cells avoid HIV-induced cell death can an effective strategy to kill infected cells be developed.",
keywords = "Apoptosis, Human immunodeficiency virus, Immune evasion, Latency",
author = "Cummins, {Nathan W} and Badley, {Andrew David}",
year = "2013",
month = "9",
doi = "10.1007/s00018-012-1239-3",
language = "English (US)",
volume = "70",
pages = "3355--3363",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "18",

}

TY - JOUR

T1 - Anti-apoptotic mechanisms of HIV

T2 - Lessons and novel approaches to curing HIV

AU - Cummins, Nathan W

AU - Badley, Andrew David

PY - 2013/9

Y1 - 2013/9

N2 - Past efforts at curing infection with the human immunodeficiency virus (HIV) have been blocked by the resistance of some infected cells to viral cytopathic effects and the associated development of a latent viral reservoir. Furthermore, current efforts to clear the viral reservoir by means of reactivating latent virus are hampered by the lack of cell death in the newly productively infected cells. The purpose of this review is to describe the many anti-apoptotic mechanisms of HIV, as well as the current limitations in the field. Only by understanding how infected cells avoid HIV-induced cell death can an effective strategy to kill infected cells be developed.

AB - Past efforts at curing infection with the human immunodeficiency virus (HIV) have been blocked by the resistance of some infected cells to viral cytopathic effects and the associated development of a latent viral reservoir. Furthermore, current efforts to clear the viral reservoir by means of reactivating latent virus are hampered by the lack of cell death in the newly productively infected cells. The purpose of this review is to describe the many anti-apoptotic mechanisms of HIV, as well as the current limitations in the field. Only by understanding how infected cells avoid HIV-induced cell death can an effective strategy to kill infected cells be developed.

KW - Apoptosis

KW - Human immunodeficiency virus

KW - Immune evasion

KW - Latency

UR - http://www.scopus.com/inward/record.url?scp=84883454797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883454797&partnerID=8YFLogxK

U2 - 10.1007/s00018-012-1239-3

DO - 10.1007/s00018-012-1239-3

M3 - Article

C2 - 23275944

AN - SCOPUS:84883454797

VL - 70

SP - 3355

EP - 3363

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 18

ER -