Anti-apoptotic mechanisms of HIV: Lessons and novel approaches to curing HIV

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Past efforts at curing infection with the human immunodeficiency virus (HIV) have been blocked by the resistance of some infected cells to viral cytopathic effects and the associated development of a latent viral reservoir. Furthermore, current efforts to clear the viral reservoir by means of reactivating latent virus are hampered by the lack of cell death in the newly productively infected cells. The purpose of this review is to describe the many anti-apoptotic mechanisms of HIV, as well as the current limitations in the field. Only by understanding how infected cells avoid HIV-induced cell death can an effective strategy to kill infected cells be developed.

Original languageEnglish (US)
Pages (from-to)3355-3363
Number of pages9
JournalCellular and Molecular Life Sciences
Volume70
Issue number18
DOIs
StatePublished - Sep 2013

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Keywords

  • Apoptosis
  • Human immunodeficiency virus
  • Immune evasion
  • Latency

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

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