Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia

Clifford R Jr. Jack, Dennis W Dickson, Joseph E Parisi, Y. C. Xu, R. H. Cha, P. C. O'Brien, S. D. Edland, G. E. Smith, Bradley F Boeve, Eric George Tangalos, E. Kokmen, Ronald Carl Petersen

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Abstract

Objectives: To assess the diagnostic specificity of MRI-defined hippocampal atrophy for AD among individuals with a variety of pathologically confirmed conditions associated with dementia as well as changes attributable to typical aging, and to measure correlations among premortem MRI measurements of hippocampal atrophy, mental status examination performance, and the pathologic stage of AD. Methods: An unselected series of 67 individuals participating in the Mayo Alzheimer's Disease Research Center/Alzheimer's Disease Patient Registry who had undergone a standardized antemortem MRI study and also postmortem examination were identified. Hippocampal volumes were measured from antemortem MRI. Each postmortem specimen was assigned a pathologic diagnosis and in addition, the severity of AD pathology was staged using the method of Braak and Braak. Results: Individuals with an isolated pathologic diagnosis of AD, hippocampal sclerosis, frontotemporal degeneration, and neurofibrillary tangle-only degeneration usually had substantial hippocampal atrophy, while those with changes of typical aging did not. Among all 67 subjects, correlations (all p < 0.001) were observed between hippocampal volume and Braak and Braak stage (r = -0.39), between hippocampal volume and Mini-Mental State Examination (MMSE) score (r = 0.60), and between MMSE score and Braak and Braak stage (r = -0.41). Conclusions: Hippocampal atrophy, while not specific for AD, was a fairly sensitive marker of the pathologic AD stage (particularly among subjects with isolated AD pathology [r = -0.63, p = 0.001]) and consequent cognitive status.

Original languageEnglish (US)
Pages (from-to)750-757
Number of pages8
JournalNeurology
Volume58
Issue number5
StatePublished - Mar 12 2002

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Atrophy
Dementia
Alzheimer Disease
Pathology
Neurofibrillary Tangles
Sclerosis
Registries
Autopsy
Neuropathology
Research

ASJC Scopus subject areas

  • Neuroscience(all)

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Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia. / Jack, Clifford R Jr.; Dickson, Dennis W; Parisi, Joseph E; Xu, Y. C.; Cha, R. H.; O'Brien, P. C.; Edland, S. D.; Smith, G. E.; Boeve, Bradley F; Tangalos, Eric George; Kokmen, E.; Petersen, Ronald Carl.

In: Neurology, Vol. 58, No. 5, 12.03.2002, p. 750-757.

Research output: Contribution to journalArticle

Jack, CRJ, Dickson, DW, Parisi, JE, Xu, YC, Cha, RH, O'Brien, PC, Edland, SD, Smith, GE, Boeve, BF, Tangalos, EG, Kokmen, E & Petersen, RC 2002, 'Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia', Neurology, vol. 58, no. 5, pp. 750-757.
Jack, Clifford R Jr. ; Dickson, Dennis W ; Parisi, Joseph E ; Xu, Y. C. ; Cha, R. H. ; O'Brien, P. C. ; Edland, S. D. ; Smith, G. E. ; Boeve, Bradley F ; Tangalos, Eric George ; Kokmen, E. ; Petersen, Ronald Carl. / Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia. In: Neurology. 2002 ; Vol. 58, No. 5. pp. 750-757.
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abstract = "Objectives: To assess the diagnostic specificity of MRI-defined hippocampal atrophy for AD among individuals with a variety of pathologically confirmed conditions associated with dementia as well as changes attributable to typical aging, and to measure correlations among premortem MRI measurements of hippocampal atrophy, mental status examination performance, and the pathologic stage of AD. Methods: An unselected series of 67 individuals participating in the Mayo Alzheimer's Disease Research Center/Alzheimer's Disease Patient Registry who had undergone a standardized antemortem MRI study and also postmortem examination were identified. Hippocampal volumes were measured from antemortem MRI. Each postmortem specimen was assigned a pathologic diagnosis and in addition, the severity of AD pathology was staged using the method of Braak and Braak. Results: Individuals with an isolated pathologic diagnosis of AD, hippocampal sclerosis, frontotemporal degeneration, and neurofibrillary tangle-only degeneration usually had substantial hippocampal atrophy, while those with changes of typical aging did not. Among all 67 subjects, correlations (all p < 0.001) were observed between hippocampal volume and Braak and Braak stage (r = -0.39), between hippocampal volume and Mini-Mental State Examination (MMSE) score (r = 0.60), and between MMSE score and Braak and Braak stage (r = -0.41). Conclusions: Hippocampal atrophy, while not specific for AD, was a fairly sensitive marker of the pathologic AD stage (particularly among subjects with isolated AD pathology [r = -0.63, p = 0.001]) and consequent cognitive status.",
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AU - Jack, Clifford R Jr.

AU - Dickson, Dennis W

AU - Parisi, Joseph E

AU - Xu, Y. C.

AU - Cha, R. H.

AU - O'Brien, P. C.

AU - Edland, S. D.

AU - Smith, G. E.

AU - Boeve, Bradley F

AU - Tangalos, Eric George

AU - Kokmen, E.

AU - Petersen, Ronald Carl

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N2 - Objectives: To assess the diagnostic specificity of MRI-defined hippocampal atrophy for AD among individuals with a variety of pathologically confirmed conditions associated with dementia as well as changes attributable to typical aging, and to measure correlations among premortem MRI measurements of hippocampal atrophy, mental status examination performance, and the pathologic stage of AD. Methods: An unselected series of 67 individuals participating in the Mayo Alzheimer's Disease Research Center/Alzheimer's Disease Patient Registry who had undergone a standardized antemortem MRI study and also postmortem examination were identified. Hippocampal volumes were measured from antemortem MRI. Each postmortem specimen was assigned a pathologic diagnosis and in addition, the severity of AD pathology was staged using the method of Braak and Braak. Results: Individuals with an isolated pathologic diagnosis of AD, hippocampal sclerosis, frontotemporal degeneration, and neurofibrillary tangle-only degeneration usually had substantial hippocampal atrophy, while those with changes of typical aging did not. Among all 67 subjects, correlations (all p < 0.001) were observed between hippocampal volume and Braak and Braak stage (r = -0.39), between hippocampal volume and Mini-Mental State Examination (MMSE) score (r = 0.60), and between MMSE score and Braak and Braak stage (r = -0.41). Conclusions: Hippocampal atrophy, while not specific for AD, was a fairly sensitive marker of the pathologic AD stage (particularly among subjects with isolated AD pathology [r = -0.63, p = 0.001]) and consequent cognitive status.

AB - Objectives: To assess the diagnostic specificity of MRI-defined hippocampal atrophy for AD among individuals with a variety of pathologically confirmed conditions associated with dementia as well as changes attributable to typical aging, and to measure correlations among premortem MRI measurements of hippocampal atrophy, mental status examination performance, and the pathologic stage of AD. Methods: An unselected series of 67 individuals participating in the Mayo Alzheimer's Disease Research Center/Alzheimer's Disease Patient Registry who had undergone a standardized antemortem MRI study and also postmortem examination were identified. Hippocampal volumes were measured from antemortem MRI. Each postmortem specimen was assigned a pathologic diagnosis and in addition, the severity of AD pathology was staged using the method of Braak and Braak. Results: Individuals with an isolated pathologic diagnosis of AD, hippocampal sclerosis, frontotemporal degeneration, and neurofibrillary tangle-only degeneration usually had substantial hippocampal atrophy, while those with changes of typical aging did not. Among all 67 subjects, correlations (all p < 0.001) were observed between hippocampal volume and Braak and Braak stage (r = -0.39), between hippocampal volume and Mini-Mental State Examination (MMSE) score (r = 0.60), and between MMSE score and Braak and Braak stage (r = -0.41). Conclusions: Hippocampal atrophy, while not specific for AD, was a fairly sensitive marker of the pathologic AD stage (particularly among subjects with isolated AD pathology [r = -0.63, p = 0.001]) and consequent cognitive status.

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