Annual incidence of nephrolithiasis among children and adults in South Carolina from 1997 to 2012

Gregory E. Tasian, Michelle E. Ross, Lihai Song, David Sas, Ron Keren, Michelle R. Denburg, David I. Chu, Lawrence Copelovitch, Christopher S. Saigal, Susan L. Furth

Research output: Contribution to journalArticle

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Abstract

Background and objectives The prevalence of nephrolithiasis in the United States has increased substantially, but recent changes in incidence with respect to age, sex, and race are not well characterized. This study examined temporal trends in the annual incidence and cumulative risk of nephrolithiasis among children and adults living in South Carolina over a 16-year period. Design, setting, participants, & measurements We performed a population-based, repeated cross-sectional study using the USCensusandSouth Carolina MedicalEncounterdata, whichcapture allemergency department visits, surgeries, and admissions in the state. The annual incidence of nephrolithiasis in South Carolina from 1997 to 2012 was estimated, and linear mixed models were used to estimate incidence rate ratios for age, sex, and racial groups. The cumulative risk of nephrolithiasis during childhood and over the lifetime was estimated for males and females in 1997 and 2012. Results Among an at-risk population of 4,625,364 people, 152,925 unique patients received emergency, inpatient, or surgical care for nephrolithiasis. Between 1997 and 2012, the mean annual incidence of nephrolithiasis increased 1% annually from 206 to 239 per 100,000 persons. Among age groups, the greatest increase was observed among 15-19 year olds, in whom incidence increased 26% per 5 years (incidence rate ratio, 1.26; 95% confidence interval, 1.22 to 1.29). Adjusting for age and race, incidence increased 15% per 5 years among females (incidence rate ratio, 1.15; 95% confidence interval, 1.14 to 1.16) but remained stable for males. The incidence among blacks increased 15% more per 5 years compared with whites (incidence rate ratio, 1.15; 95% confidence interval, 1.14 to 1.17). These changes in incidence resulted in doubling of the risk of nephrolithiasis during childhood and a 45% increase in the lifetime risk of nephrolithiasis for women over the study period. Conclusions The incidence of kidney stones has increased among young patients, particularly women, and blacks.

Original languageEnglish (US)
Pages (from-to)488-496
Number of pages9
JournalClinical Journal of the American Society of Nephrology
Volume11
Issue number3
DOIs
StatePublished - Mar 7 2016

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Nephrolithiasis
Incidence
Confidence Intervals
Kidney Calculi
Sex Ratio
Inpatients
Linear Models

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

Cite this

Annual incidence of nephrolithiasis among children and adults in South Carolina from 1997 to 2012. / Tasian, Gregory E.; Ross, Michelle E.; Song, Lihai; Sas, David; Keren, Ron; Denburg, Michelle R.; Chu, David I.; Copelovitch, Lawrence; Saigal, Christopher S.; Furth, Susan L.

In: Clinical Journal of the American Society of Nephrology, Vol. 11, No. 3, 07.03.2016, p. 488-496.

Research output: Contribution to journalArticle

Tasian, GE, Ross, ME, Song, L, Sas, D, Keren, R, Denburg, MR, Chu, DI, Copelovitch, L, Saigal, CS & Furth, SL 2016, 'Annual incidence of nephrolithiasis among children and adults in South Carolina from 1997 to 2012', Clinical Journal of the American Society of Nephrology, vol. 11, no. 3, pp. 488-496. https://doi.org/10.2215/CJN.07610715
Tasian, Gregory E. ; Ross, Michelle E. ; Song, Lihai ; Sas, David ; Keren, Ron ; Denburg, Michelle R. ; Chu, David I. ; Copelovitch, Lawrence ; Saigal, Christopher S. ; Furth, Susan L. / Annual incidence of nephrolithiasis among children and adults in South Carolina from 1997 to 2012. In: Clinical Journal of the American Society of Nephrology. 2016 ; Vol. 11, No. 3. pp. 488-496.
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abstract = "Background and objectives The prevalence of nephrolithiasis in the United States has increased substantially, but recent changes in incidence with respect to age, sex, and race are not well characterized. This study examined temporal trends in the annual incidence and cumulative risk of nephrolithiasis among children and adults living in South Carolina over a 16-year period. Design, setting, participants, & measurements We performed a population-based, repeated cross-sectional study using the USCensusandSouth Carolina MedicalEncounterdata, whichcapture allemergency department visits, surgeries, and admissions in the state. The annual incidence of nephrolithiasis in South Carolina from 1997 to 2012 was estimated, and linear mixed models were used to estimate incidence rate ratios for age, sex, and racial groups. The cumulative risk of nephrolithiasis during childhood and over the lifetime was estimated for males and females in 1997 and 2012. Results Among an at-risk population of 4,625,364 people, 152,925 unique patients received emergency, inpatient, or surgical care for nephrolithiasis. Between 1997 and 2012, the mean annual incidence of nephrolithiasis increased 1{\%} annually from 206 to 239 per 100,000 persons. Among age groups, the greatest increase was observed among 15-19 year olds, in whom incidence increased 26{\%} per 5 years (incidence rate ratio, 1.26; 95{\%} confidence interval, 1.22 to 1.29). Adjusting for age and race, incidence increased 15{\%} per 5 years among females (incidence rate ratio, 1.15; 95{\%} confidence interval, 1.14 to 1.16) but remained stable for males. The incidence among blacks increased 15{\%} more per 5 years compared with whites (incidence rate ratio, 1.15; 95{\%} confidence interval, 1.14 to 1.17). These changes in incidence resulted in doubling of the risk of nephrolithiasis during childhood and a 45{\%} increase in the lifetime risk of nephrolithiasis for women over the study period. Conclusions The incidence of kidney stones has increased among young patients, particularly women, and blacks.",
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AU - Ross, Michelle E.

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AU - Sas, David

AU - Keren, Ron

AU - Denburg, Michelle R.

AU - Chu, David I.

AU - Copelovitch, Lawrence

AU - Saigal, Christopher S.

AU - Furth, Susan L.

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