Animal models of brain tumor surgery

Montserrat Lara-Velazquez; Stephanie Jeanneret; Paula Schiapparelli; Hugo Guerrero-Cazares

doi:10.1016/B978-0-12-811783-5.00009-4

Animal models of brain tumor surgery

Montserrat Lara-Velazquez, Stephanie Jeanneret, Paula Schiapparelli, Hugo Guerrero-Cazares

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The elucidation and understanding of cancer biology is essential for brain cancer treatment. Despite advancements in surgery and chemoradiation, glioma tumor patients remain living with short life expectancies after diagnosis. Animal models that allow the replication of anatomical and molecular findings of human cancer are thus a necessary approach for cancer research. They have allowed scientists to investigate the mechanisms involved in early tumorigenesis, therapy resistance, and tumor recurrence. Furthermore, the development of such models has refined brain surgery techniques, allowing for successful tumor resections. In addition, personalized medical approaches such as preclinical models have improved the prediction of patients’ cancer cell responses to specific conditions.

Original language	English (US)
Title of host publication	Comprehensive Overview of Modern Surgical Approaches to Intrinsic Brain Tumors
Publisher	Elsevier
Pages	169-190
Number of pages	22
ISBN (Electronic)	9780128117835
ISBN (Print)	9780128117842
DOIs	https://doi.org/10.1016/B978-0-12-811783-5.00009-4
State	Published - Jan 1 2019

Keywords

Animal surgery model
Brain local therapy
In vivo glioblastoma surgical model
Optimized surgical technique
Orthotopic transplant and resection

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-12-811783-5.00009-4

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AU - Jeanneret, Stephanie

AU - Schiapparelli, Paula

AU - Guerrero-Cazares, Hugo

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AB - The elucidation and understanding of cancer biology is essential for brain cancer treatment. Despite advancements in surgery and chemoradiation, glioma tumor patients remain living with short life expectancies after diagnosis. Animal models that allow the replication of anatomical and molecular findings of human cancer are thus a necessary approach for cancer research. They have allowed scientists to investigate the mechanisms involved in early tumorigenesis, therapy resistance, and tumor recurrence. Furthermore, the development of such models has refined brain surgery techniques, allowing for successful tumor resections. In addition, personalized medical approaches such as preclinical models have improved the prediction of patients’ cancer cell responses to specific conditions.

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KW - Brain local therapy

KW - In vivo glioblastoma surgical model

KW - Optimized surgical technique

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Animal models of brain tumor surgery

Abstract

Keywords

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