Animal models of brain tumor surgery

Montserrat Lara-Velazquez, Stephanie Jeanneret, Paula Schiapparelli, Hugo Guerrero-Cazares

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The elucidation and understanding of cancer biology is essential for brain cancer treatment. Despite advancements in surgery and chemoradiation, glioma tumor patients remain living with short life expectancies after diagnosis. Animal models that allow the replication of anatomical and molecular findings of human cancer are thus a necessary approach for cancer research. They have allowed scientists to investigate the mechanisms involved in early tumorigenesis, therapy resistance, and tumor recurrence. Furthermore, the development of such models has refined brain surgery techniques, allowing for successful tumor resections. In addition, personalized medical approaches such as preclinical models have improved the prediction of patients’ cancer cell responses to specific conditions.

Original languageEnglish (US)
Title of host publicationComprehensive Overview of Modern Surgical Approaches to Intrinsic Brain Tumors
PublisherElsevier
Pages169-190
Number of pages22
ISBN (Electronic)9780128117835
ISBN (Print)9780128117842
DOIs
StatePublished - Jan 1 2019

Keywords

  • Animal surgery model
  • Brain local therapy
  • In vivo glioblastoma surgical model
  • Optimized surgical technique
  • Orthotopic transplant and resection

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Lara-Velazquez, M., Jeanneret, S., Schiapparelli, P., & Guerrero-Cazares, H. (2019). Animal models of brain tumor surgery. In Comprehensive Overview of Modern Surgical Approaches to Intrinsic Brain Tumors (pp. 169-190). Elsevier. https://doi.org/10.1016/B978-0-12-811783-5.00009-4