Angiotensin-converting enzyme activity decreases during fasting

N. E. Butkus, K. D. Burman, Robert Christian Smallridge

Research output: Contribution to journalArticle

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Abstract

Serum angiotensin-converting enzyme (ACE) activity varies directly with thyroid hormone levels in states of altered thyroid function. Because T3 levels decrease during fasting, ACE activity was examined to ascertain if it was reduced in this low T3 condition. Eighteen obese euthyroid subjects were hospitalized and placed on a weight-maintaining diet for 4 days. Nine subjects (Group 1) underwent a fast (50 kcal/day) for 8 days. Nine (Group 2) subjects received T3 (5 μg q 3 h) during an identical fast. Weight loss was identical in both groups (-4.4 kg). Serum T3 fell in Group 1 from 104 ± 8 to 50 ± 4 ng/d/(p<.05) but was unchanged in Group 2 (114 ± 11 ng/dl fed vs. 120 ± 14 ng/dl fasted). Blood pressures fell significantly in Group 1 (mean systolic: 112 → 104 mmHg; diastolic: 71 → 65 mmHg, p<0.05), but not in Group 2 subjects. ACE activity fell progressively in Group 1 subjects during fasting (14.4 ± 1.6 U/ml fed vs. 12.8 ± 1.4 U/ml fasted p<0.05). ACE activity was not decreased significantly early in the fast in patients given T3, but by late fast (days 6-8) was reduced to the same degree as in Group 1 subjects. Glucose and insulin levels fell similarly in both groups. Conclusions: (1) ACE activity is reduced during starvation. This effect is not mediated by T3. (2) Blood pressure reduction during fasting may result from the low T3 levels, but not from decreased ACE activity. Interpretation of serum ACE activity must be viewed in the context of a patient's diet.

Original languageEnglish (US)
Pages (from-to)76-79
Number of pages4
JournalHormone and Metabolic Research
Volume19
Issue number2
StatePublished - 1987
Externally publishedYes

Fingerprint

Enzyme activity
Peptidyl-Dipeptidase A
Fasting
Blood pressure
Nutrition
Serum
Diet
Blood Pressure
Starvation
Thyroid Hormones
Weight Loss
Thyroid Gland
Insulin
Weights and Measures
Glucose

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Angiotensin-converting enzyme activity decreases during fasting. / Butkus, N. E.; Burman, K. D.; Smallridge, Robert Christian.

In: Hormone and Metabolic Research, Vol. 19, No. 2, 1987, p. 76-79.

Research output: Contribution to journalArticle

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