Angiosarcoma outcomes and prognostic factors: A 25-year single institution experience

Darya Buehler, Stephanie R. Rice, John S. Moody, Patrick Rush, Gholam Reza Hafez, Steven Attia, B. Jack Longley, Kevin R. Kozak

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Objective: Angiosarcoma is an aggressive malignancy with endothelial differentiation and notoriously poor prognosis despite aggressive therapy. Limited data are available to guide management decisions. To address this limitation, we present a large retrospective analysis of angiosarcoma patients treated at a single institution over a 25-year period.

Methods: To identify factors that impact angiosarcoma outcomes, we reviewed demographic, tumor, and treatment characteristics of angiosarcoma patients evaluated at the University of Wisconsin Hospital between 1987 and 2012.

Results: The cohort included 81 patients diagnosed at ages 19 to 90 years (median, 67y). Fifty-five (68%) patients presented with localized disease, whereas 26 (32%) presented with metastases. The primary sites were visceral/deep soft tissue (42%), head and neck/cutaneous (37%), breast (16%), and limbs in the setting of Stewart-Treves (5%). The 5-year overall survival was 40% with a median of 16 months. By univariate analysis, significant adverse predictors of survival included metastases at presentation, visceral/deep soft tissue tumor location, tumor size>5cm, tumor necrosis, and the absence of surgical excision. A trend toward prolonged survival was observed with radiation therapy and for chemotherapy in patients with metastases. Age, sex, and prior radiation showed no correlation with survival.

Conclusions: Our large single institution series confirms the poor prognosis of angiosarcoma, supports a central role for surgical excision in management, and highlights the need for novel therapies particularly in patients who present with metastatic disease.

Original languageEnglish (US)
Pages (from-to)473-479
Number of pages7
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Issue number5
StatePublished - 2013


  • Angiosarcoma
  • Retrospective study
  • Sarcoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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