TY - JOUR
T1 - Angina in idiopathic hypertrophic subaortic stenosis. A clinical correlate of regional left ventricular dysfunction
T2 - A videometric and echocardiographic study
AU - Sutton, M. G.S.J.
AU - Tajik, A. J.
AU - Smith, H. C.
AU - Ritman, E. L.
PY - 1980
Y1 - 1980
N2 - Angina, dyspnea and syncope often occur in idiopathic hypertrophic subaortic stenosis (IHSS), but have not hitherto been correlated with conventional measures of left ventricular (LV) function. We assessed regional and global LV function in 18 patients with IHSS by roentgen videometric analysis of biplane left ventriculograms and M-mode echocardiography to investigate 1) whether any relationship could be demonstrated between symptoms and global or regional LV function, and 2) how normal or supernormal global function could be maintained in the presence of severe septal hypokinesis. Syncope occurred in four patients with IHSS, angina in seven and dyspnea in 11. No correlation was demonstrable between any symptom and any measure of global LV function, or between syncope and dyspnea and regional LV function. However, a correlation was shown between angina and regional function in that peak rates of systolic thickening and diastolic thinning of the anterior LV wall in these patients were significantly (p < 0.01) less than in patients without angina. In view of the documented relationship between myocardial ischemia and regional wall dynamics, we conclude that angina in IHSS in the absence of coronary artery disease is strongly associated with impaired wall dynamics, although which is cause and which is effect is unresolved. useful may therefore be uselul as an indicator of regional LV dysfunction. Furthermore, the normal pump function is maintained by increased cavity emptying.
AB - Angina, dyspnea and syncope often occur in idiopathic hypertrophic subaortic stenosis (IHSS), but have not hitherto been correlated with conventional measures of left ventricular (LV) function. We assessed regional and global LV function in 18 patients with IHSS by roentgen videometric analysis of biplane left ventriculograms and M-mode echocardiography to investigate 1) whether any relationship could be demonstrated between symptoms and global or regional LV function, and 2) how normal or supernormal global function could be maintained in the presence of severe septal hypokinesis. Syncope occurred in four patients with IHSS, angina in seven and dyspnea in 11. No correlation was demonstrable between any symptom and any measure of global LV function, or between syncope and dyspnea and regional LV function. However, a correlation was shown between angina and regional function in that peak rates of systolic thickening and diastolic thinning of the anterior LV wall in these patients were significantly (p < 0.01) less than in patients without angina. In view of the documented relationship between myocardial ischemia and regional wall dynamics, we conclude that angina in IHSS in the absence of coronary artery disease is strongly associated with impaired wall dynamics, although which is cause and which is effect is unresolved. useful may therefore be uselul as an indicator of regional LV dysfunction. Furthermore, the normal pump function is maintained by increased cavity emptying.
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U2 - 10.1161/01.CIR.61.3.561
DO - 10.1161/01.CIR.61.3.561
M3 - Article
C2 - 7188738
AN - SCOPUS:0018864490
SN - 0009-7322
VL - 61
SP - 561
EP - 568
JO - Circulation
JF - Circulation
IS - 3
ER -