Analysis of the Type 2 Diabetes-Associated Single Nucleotide Polymorphisms in the Genes IRS1, KCNJ11, and PPARG2 in Type 1 Diabetes

Christina Eftychi, Joanna M M Howson, Bryan J. Barratt, Adrian Vella, Felicity Payne, Deborah J. Smyth, Rebecca C J Twells, Neil M. Walker, Helen E. Rance, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Dag E. Undlien, Kjersti S. Rønningen, Cristian Guja, Constantin Ionescu-Tîrgovişte, David A. Savage, John A. Todd

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Abstract

It has been proposed that type 1 and 2 diabetes might share common pathophysiological pathways and, to some extent, genetic background. However, to date there has been no convincing data to establish a molecular genetic link between them. We have genotyped three single nucleotide polymorphisms associated with type 2 diabetes in a large type 1 diabetic family collection of European descent: Gly972Arg in the insulin receptor substrate 1 (IRS1) gene, Glu23Lys in the potassium inwardly-rectifying channel gene (KCNJ11), and Pro12Ala in the peroxisome proliferative-activated receptor γ2 gene (PPARG2). We were unable to confirm a recently published association of the IRS1 Gly972Arg variant with type 1 diabetes. Moreover, KCNJ11 Glu23Lys showed no association with type 1 diabetes (P > 0.05). However, the PPARG2 Pro12Ala variant showed evidence of association (RR 1.15, 95% CI 1.04-1.28, P = 0.008). Additional studies need to be conducted to confirm this result.

Original languageEnglish (US)
Pages (from-to)870-873
Number of pages4
JournalDiabetes
Volume53
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

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ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Eftychi, C., Howson, J. M. M., Barratt, B. J., Vella, A., Payne, F., Smyth, D. J., Twells, R. C. J., Walker, N. M., Rance, H. E., Tuomilehto-Wolf, E., Tuomilehto, J., Undlien, D. E., Rønningen, K. S., Guja, C., Ionescu-Tîrgovişte, C., Savage, D. A., & Todd, J. A. (2004). Analysis of the Type 2 Diabetes-Associated Single Nucleotide Polymorphisms in the Genes IRS1, KCNJ11, and PPARG2 in Type 1 Diabetes. Diabetes, 53(3), 870-873. https://doi.org/10.2337/diabetes.53.3.870