Analysis of the Type 2 Diabetes-Associated Single Nucleotide Polymorphisms in the Genes IRS1, KCNJ11, and PPARG2 in Type 1 Diabetes

Christina Eftychi, Joanna M M Howson, Bryan J. Barratt, Adrian Vella, Felicity Payne, Deborah J. Smyth, Rebecca C J Twells, Neil M. Walker, Helen E. Rance, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Dag E. Undlien, Kjersti S. Rønningen, Cristian Guja, Constantin Ionescu-Tîrgovişte, David A. Savage, John A. Todd

Research output: Contribution to journalArticle

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Abstract

It has been proposed that type 1 and 2 diabetes might share common pathophysiological pathways and, to some extent, genetic background. However, to date there has been no convincing data to establish a molecular genetic link between them. We have genotyped three single nucleotide polymorphisms associated with type 2 diabetes in a large type 1 diabetic family collection of European descent: Gly972Arg in the insulin receptor substrate 1 (IRS1) gene, Glu23Lys in the potassium inwardly-rectifying channel gene (KCNJ11), and Pro12Ala in the peroxisome proliferative-activated receptor γ2 gene (PPARG2). We were unable to confirm a recently published association of the IRS1 Gly972Arg variant with type 1 diabetes. Moreover, KCNJ11 Glu23Lys showed no association with type 1 diabetes (P > 0.05). However, the PPARG2 Pro12Ala variant showed evidence of association (RR 1.15, 95% CI 1.04-1.28, P = 0.008). Additional studies need to be conducted to confirm this result.

Original languageEnglish (US)
Pages (from-to)870-873
Number of pages4
JournalDiabetes
Volume53
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

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Insulin Receptor Substrate Proteins
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
Genes
Inwardly Rectifying Potassium Channel
Peroxisomes
Molecular Biology

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Analysis of the Type 2 Diabetes-Associated Single Nucleotide Polymorphisms in the Genes IRS1, KCNJ11, and PPARG2 in Type 1 Diabetes. / Eftychi, Christina; Howson, Joanna M M; Barratt, Bryan J.; Vella, Adrian; Payne, Felicity; Smyth, Deborah J.; Twells, Rebecca C J; Walker, Neil M.; Rance, Helen E.; Tuomilehto-Wolf, Eva; Tuomilehto, Jaakko; Undlien, Dag E.; Rønningen, Kjersti S.; Guja, Cristian; Ionescu-Tîrgovişte, Constantin; Savage, David A.; Todd, John A.

In: Diabetes, Vol. 53, No. 3, 03.2004, p. 870-873.

Research output: Contribution to journalArticle

Eftychi, C, Howson, JMM, Barratt, BJ, Vella, A, Payne, F, Smyth, DJ, Twells, RCJ, Walker, NM, Rance, HE, Tuomilehto-Wolf, E, Tuomilehto, J, Undlien, DE, Rønningen, KS, Guja, C, Ionescu-Tîrgovişte, C, Savage, DA & Todd, JA 2004, 'Analysis of the Type 2 Diabetes-Associated Single Nucleotide Polymorphisms in the Genes IRS1, KCNJ11, and PPARG2 in Type 1 Diabetes', Diabetes, vol. 53, no. 3, pp. 870-873. https://doi.org/10.2337/diabetes.53.3.870
Eftychi, Christina ; Howson, Joanna M M ; Barratt, Bryan J. ; Vella, Adrian ; Payne, Felicity ; Smyth, Deborah J. ; Twells, Rebecca C J ; Walker, Neil M. ; Rance, Helen E. ; Tuomilehto-Wolf, Eva ; Tuomilehto, Jaakko ; Undlien, Dag E. ; Rønningen, Kjersti S. ; Guja, Cristian ; Ionescu-Tîrgovişte, Constantin ; Savage, David A. ; Todd, John A. / Analysis of the Type 2 Diabetes-Associated Single Nucleotide Polymorphisms in the Genes IRS1, KCNJ11, and PPARG2 in Type 1 Diabetes. In: Diabetes. 2004 ; Vol. 53, No. 3. pp. 870-873.
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