Analysis of Second Primary Lung Cancers in the SEER Database

Amrit Bhaskarla, Paul C. Tang, Terry Mashtare, Chukwumere E. Nwogu, Todd L. Demmy, Alex Adjei, Mary E. Reid, Sai Yendamuri

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: We sought to examine the outcomes of second primary lung cancers in the large population-based Surveillance Epidemiology and End Results (SEER) database. We also sought to study the outcomes of synchronous second non-small-cell lung cancers (NSCLCs), classified as stage IVA (M1A) according to the seventh edition of the TNM staging for lung cancer. Methods: Data of patients with at least two primary lung cancers were obtained. All available variables potentially associated with the incidence of a second primary lung cancer were examined. The overall survival of patients with synchronous NSCLC was compared with those with metachronous and stage IV NSCLC. Results: A small proportion (1.5%) of patients with lung cancer developed a second primary. A second primary is associated with younger age, female gender, earlier stage, and white race. The median survival of patients with metachronous NSCLCs (n = 3352) was worse than those with synchronous NSCLCs (n = 1858) (median survival 22 mo versus 29 mo, respectively; P < 0.01). After adjusting for age, race, gender, stage, and histology of both primaries, this difference in survival between patients with synchronous and metachronous second primary lung cancers was not statistically significant, but was better than those with stage IV NSCLC (n = 127,654; median survival 4 mo). Conclusions: The incidence of second primary lung cancer is lower than that previously reported. Factors associated with good prognosis predict a second primary. Synchronous NSCLCs have an outcome better than a stage IV (M1a) designation. These patients should receive appropriate stage-specific multi-modality therapy suitable for the independent stage of each cancer without considering them unresectable.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Surgical Research
Volume162
Issue number1
DOIs
StatePublished - Jul 1 2010
Externally publishedYes

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Second Primary Neoplasms
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Epidemiology
Databases
Survival
Population Surveillance
Neoplasm Staging
Incidence
Histology
Outcome Assessment (Health Care)
Neoplasms

Keywords

  • lung cancer
  • SEER
  • synchronous

ASJC Scopus subject areas

  • Surgery

Cite this

Bhaskarla, A., Tang, P. C., Mashtare, T., Nwogu, C. E., Demmy, T. L., Adjei, A., ... Yendamuri, S. (2010). Analysis of Second Primary Lung Cancers in the SEER Database. Journal of Surgical Research, 162(1), 1-6. https://doi.org/10.1016/j.jss.2009.12.030

Analysis of Second Primary Lung Cancers in the SEER Database. / Bhaskarla, Amrit; Tang, Paul C.; Mashtare, Terry; Nwogu, Chukwumere E.; Demmy, Todd L.; Adjei, Alex; Reid, Mary E.; Yendamuri, Sai.

In: Journal of Surgical Research, Vol. 162, No. 1, 01.07.2010, p. 1-6.

Research output: Contribution to journalArticle

Bhaskarla, A, Tang, PC, Mashtare, T, Nwogu, CE, Demmy, TL, Adjei, A, Reid, ME & Yendamuri, S 2010, 'Analysis of Second Primary Lung Cancers in the SEER Database', Journal of Surgical Research, vol. 162, no. 1, pp. 1-6. https://doi.org/10.1016/j.jss.2009.12.030
Bhaskarla, Amrit ; Tang, Paul C. ; Mashtare, Terry ; Nwogu, Chukwumere E. ; Demmy, Todd L. ; Adjei, Alex ; Reid, Mary E. ; Yendamuri, Sai. / Analysis of Second Primary Lung Cancers in the SEER Database. In: Journal of Surgical Research. 2010 ; Vol. 162, No. 1. pp. 1-6.
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