Analysis of laboratory-frame and rotating-frame cross-relaxation buildup rates from macromolecules

Jasna Fejzo, Zsolt Zolnai, Slobodan Macura, John L. Markley

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

A quadratic approximation of cross-relaxation buildup rates is described for identifying and correcting for indirect magnetization transfer effects in macromolecular spectra. This approach has permitted the accurate determination of interproton distances in a protein of molecular weight 6000, turkey ovomucoid third domain. An illustration is given of the analysis of a three-spin system to yield a distance between two protons that lacked resolved direct NOESY and ROESY cross peaks.

Original languageEnglish (US)
Pages (from-to)518-528
Number of pages11
JournalJournal of Magnetic Resonance (1969)
Volume82
Issue number3
DOIs
StatePublished - May 1989

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