An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese

Guoliang Zhang, Xinchun Chen, Long Chan, Mingxia Zhang, Baohua Zhu, Lantian Wang, Xiuyun Zhu, Jieyun Zhang, Boping Zhou, Junwen Wang

Research output: Contribution to journalArticle

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Abstract

Recent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The SNP shows associations with p-values of 0.028 and 0.034 respectively, and a combined p-value of 0.0086, with odds ratio at 0.65 (95% confidence interval 0.45-0.90). We further validated the association with an independent cohort (413 cases and 241 controls in Chinese). Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations.

Original languageEnglish (US)
Article number20
JournalScientific Reports
Volume1
DOIs
StatePublished - 2011
Externally publishedYes

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Single Nucleotide Polymorphism
Tuberculosis
Alleles
Genetic Promoter Regions
Genes
Case-Control Studies
Odds Ratio
interleukin-22
Confidence Intervals

ASJC Scopus subject areas

  • General

Cite this

An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese. / Zhang, Guoliang; Chen, Xinchun; Chan, Long; Zhang, Mingxia; Zhu, Baohua; Wang, Lantian; Zhu, Xiuyun; Zhang, Jieyun; Zhou, Boping; Wang, Junwen.

In: Scientific Reports, Vol. 1, 20, 2011.

Research output: Contribution to journalArticle

Zhang, Guoliang ; Chen, Xinchun ; Chan, Long ; Zhang, Mingxia ; Zhu, Baohua ; Wang, Lantian ; Zhu, Xiuyun ; Zhang, Jieyun ; Zhou, Boping ; Wang, Junwen. / An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese. In: Scientific Reports. 2011 ; Vol. 1.
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AU - Chan, Long

AU - Zhang, Mingxia

AU - Zhu, Baohua

AU - Wang, Lantian

AU - Zhu, Xiuyun

AU - Zhang, Jieyun

AU - Zhou, Boping

AU - Wang, Junwen

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