An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese

Guoliang Zhang, Xinchun Chen, Long Chan, Mingxia Zhang, Baohua Zhu, Lantian Wang, Xiuyun Zhu, Jieyun Zhang, Boping Zhou, Junwen Wang

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31 Scopus citations

Abstract

Recent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The SNP shows associations with p-values of 0.028 and 0.034 respectively, and a combined p-value of 0.0086, with odds ratio at 0.65 (95% confidence interval 0.45-0.90). We further validated the association with an independent cohort (413 cases and 241 controls in Chinese). Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations.

Original languageEnglish (US)
Article number20
JournalScientific reports
Volume1
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • General

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    Zhang, G., Chen, X., Chan, L., Zhang, M., Zhu, B., Wang, L., Zhu, X., Zhang, J., Zhou, B., & Wang, J. (2011). An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese. Scientific reports, 1, [20]. https://doi.org/10.1038/srep00020