An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints

Nam Vo, Laura J. Niedernhofer, Luigi Aurelio Nasto, Lloydine Jacobs, Paul D. Robbins, James Kang, Christopher H Evans

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

As human lifespan increases so does the incidence of age-associated degenerative joint diseases, resulting in significant negative socioeconomic consequences. Osteoarthritis (OA) and intervertebral disc degeneration (IDD) are the most common underlying causes of joint-related chronic disability and debilitating pain in the elderly. Current treatment methods are generally not effective and involve either symptomatic relief with non-steroidal anti-inflammatory drugs and physical therapy or surgery when conservative treatments fail. The limitation in treatment options is due to our incomplete knowledge of the molecular mechanism of degeneration of articular cartilage and disc tissue. Basic understanding of the age-related changes in joint tissue is thus needed to combat the adverse effects of aging on joint health. Aging is caused at least in part by time-dependent accumulation of damaged organelles and macromolecules, leading to cell death and senescence and the eventual loss of multipotent stem cells and tissue regenerative capacity. Studies over the past decades have uncovered a number of important molecular and cellular changes in joint tissues with age. However, the precise causes of damage, cellular targets of damage, and cellular responses to damage remain poorly understood. The objectives of this review are to provide an overview of the current knowledge about the sources of endogenous and exogenous damaging agents and how they contribute to age-dependent degenerative joint disease, and highlight animal models of accelerated aging that could potentially be useful for identifying causes of and therapies for degenerative joint diseases.

Original languageEnglish (US)
Pages (from-to)831-837
Number of pages7
JournalJournal of Orthopaedic Research
Volume31
Issue number6
DOIs
StatePublished - Jun 2013
Externally publishedYes

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Osteoarthritis
Spine
Animal Models
Joints
Multipotent Stem Cells
Intervertebral Disc Degeneration
Cell Aging
Articular Cartilage
Organelles
Cell Death
Anti-Inflammatory Agents
Therapeutics
Drug Therapy
Pain
Incidence
Health

Keywords

  • aging
  • DNA repair
  • intervertebral disc
  • oxidative damage
  • synovial joints

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints. / Vo, Nam; Niedernhofer, Laura J.; Nasto, Luigi Aurelio; Jacobs, Lloydine; Robbins, Paul D.; Kang, James; Evans, Christopher H.

In: Journal of Orthopaedic Research, Vol. 31, No. 6, 06.2013, p. 831-837.

Research output: Contribution to journalArticle

Vo, Nam ; Niedernhofer, Laura J. ; Nasto, Luigi Aurelio ; Jacobs, Lloydine ; Robbins, Paul D. ; Kang, James ; Evans, Christopher H. / An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints. In: Journal of Orthopaedic Research. 2013 ; Vol. 31, No. 6. pp. 831-837.
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