An investigation of the biological basis of an interaction of abdominal fat distribution and family history of breast cancer. A nested study of sisters in the Iowa Women's Health Study (United States)

Janet E Olson, Kristen E. Anderson, James R Cerhan, Aaron R. Follsom, Thomas A. Sellers

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: The present study examined whether levels of testosterone, sex hormone binding globulin (SHBG), or insulin levels might underlie an increased risk of postmenopausal breast cancer in women with both high waist-tohip ratio and a family history of breast cancer disease that was noted earlier in the Iowa Women's Health Study. Methods: Participants for the current study were selected from 1922 sister groups (3978 women) in the Iowa Women's Health Study cohort. Two groups were included: (1) those with no family history of breast cancer and at least one sister with a high waist-to-hip ratio; or (2) those with a positive family history of breast cancer and at least one sister with a high waist-to-hip ratio. Testosterone, SHBG and insulin were measured by radioimmunoassay from 245 fasting blood samples. Results: Familial correlations among members of 66 families were estimated at 0.32, 0.28 and 0.25 for serum insulin, free testosterone and SHBG; respectively. Fasting serum insulin was significantly higher in breast cancer family history negative women than in family history positive women, in direct opposition to our a priori hypothesis. No significant differences were observed in serum SHBG or free testosterone across family history categories. Conclusion: This study corroborates a genetic component to fasting serum insulin, free testosterone and SHBG levels. It seems unlikely that insulin, SHBG, or testosterone explain the interaction between waist-to-hip ratio and family history of breast cancer among participants in the Iowa Women's Health Study.

Original languageEnglish (US)
Pages (from-to)941-954
Number of pages14
JournalCancer Causes and Control
Volume11
Issue number10
DOIs
StatePublished - 2000

Fingerprint

Abdominal Fat
Women's Health
Sex Hormone-Binding Globulin
Siblings
Breast Neoplasms
Testosterone
Insulin
Waist-Hip Ratio
Fasting
Serum
Serum Globulins
Breast Diseases
Radioimmunoassay
Cohort Studies

Keywords

  • Adipose tissue
  • Breast neoplasms
  • Insulin

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

@article{0c5231a392f445a78b4199c8f7cc513c,
title = "An investigation of the biological basis of an interaction of abdominal fat distribution and family history of breast cancer. A nested study of sisters in the Iowa Women's Health Study (United States)",
abstract = "Objective: The present study examined whether levels of testosterone, sex hormone binding globulin (SHBG), or insulin levels might underlie an increased risk of postmenopausal breast cancer in women with both high waist-tohip ratio and a family history of breast cancer disease that was noted earlier in the Iowa Women's Health Study. Methods: Participants for the current study were selected from 1922 sister groups (3978 women) in the Iowa Women's Health Study cohort. Two groups were included: (1) those with no family history of breast cancer and at least one sister with a high waist-to-hip ratio; or (2) those with a positive family history of breast cancer and at least one sister with a high waist-to-hip ratio. Testosterone, SHBG and insulin were measured by radioimmunoassay from 245 fasting blood samples. Results: Familial correlations among members of 66 families were estimated at 0.32, 0.28 and 0.25 for serum insulin, free testosterone and SHBG; respectively. Fasting serum insulin was significantly higher in breast cancer family history negative women than in family history positive women, in direct opposition to our a priori hypothesis. No significant differences were observed in serum SHBG or free testosterone across family history categories. Conclusion: This study corroborates a genetic component to fasting serum insulin, free testosterone and SHBG levels. It seems unlikely that insulin, SHBG, or testosterone explain the interaction between waist-to-hip ratio and family history of breast cancer among participants in the Iowa Women's Health Study.",
keywords = "Adipose tissue, Breast neoplasms, Insulin",
author = "Olson, {Janet E} and Anderson, {Kristen E.} and Cerhan, {James R} and Follsom, {Aaron R.} and Sellers, {Thomas A.}",
year = "2000",
doi = "10.1023/A:1026537819055",
language = "English (US)",
volume = "11",
pages = "941--954",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "10",

}

TY - JOUR

T1 - An investigation of the biological basis of an interaction of abdominal fat distribution and family history of breast cancer. A nested study of sisters in the Iowa Women's Health Study (United States)

AU - Olson, Janet E

AU - Anderson, Kristen E.

AU - Cerhan, James R

AU - Follsom, Aaron R.

AU - Sellers, Thomas A.

PY - 2000

Y1 - 2000

N2 - Objective: The present study examined whether levels of testosterone, sex hormone binding globulin (SHBG), or insulin levels might underlie an increased risk of postmenopausal breast cancer in women with both high waist-tohip ratio and a family history of breast cancer disease that was noted earlier in the Iowa Women's Health Study. Methods: Participants for the current study were selected from 1922 sister groups (3978 women) in the Iowa Women's Health Study cohort. Two groups were included: (1) those with no family history of breast cancer and at least one sister with a high waist-to-hip ratio; or (2) those with a positive family history of breast cancer and at least one sister with a high waist-to-hip ratio. Testosterone, SHBG and insulin were measured by radioimmunoassay from 245 fasting blood samples. Results: Familial correlations among members of 66 families were estimated at 0.32, 0.28 and 0.25 for serum insulin, free testosterone and SHBG; respectively. Fasting serum insulin was significantly higher in breast cancer family history negative women than in family history positive women, in direct opposition to our a priori hypothesis. No significant differences were observed in serum SHBG or free testosterone across family history categories. Conclusion: This study corroborates a genetic component to fasting serum insulin, free testosterone and SHBG levels. It seems unlikely that insulin, SHBG, or testosterone explain the interaction between waist-to-hip ratio and family history of breast cancer among participants in the Iowa Women's Health Study.

AB - Objective: The present study examined whether levels of testosterone, sex hormone binding globulin (SHBG), or insulin levels might underlie an increased risk of postmenopausal breast cancer in women with both high waist-tohip ratio and a family history of breast cancer disease that was noted earlier in the Iowa Women's Health Study. Methods: Participants for the current study were selected from 1922 sister groups (3978 women) in the Iowa Women's Health Study cohort. Two groups were included: (1) those with no family history of breast cancer and at least one sister with a high waist-to-hip ratio; or (2) those with a positive family history of breast cancer and at least one sister with a high waist-to-hip ratio. Testosterone, SHBG and insulin were measured by radioimmunoassay from 245 fasting blood samples. Results: Familial correlations among members of 66 families were estimated at 0.32, 0.28 and 0.25 for serum insulin, free testosterone and SHBG; respectively. Fasting serum insulin was significantly higher in breast cancer family history negative women than in family history positive women, in direct opposition to our a priori hypothesis. No significant differences were observed in serum SHBG or free testosterone across family history categories. Conclusion: This study corroborates a genetic component to fasting serum insulin, free testosterone and SHBG levels. It seems unlikely that insulin, SHBG, or testosterone explain the interaction between waist-to-hip ratio and family history of breast cancer among participants in the Iowa Women's Health Study.

KW - Adipose tissue

KW - Breast neoplasms

KW - Insulin

UR - http://www.scopus.com/inward/record.url?scp=0034535907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034535907&partnerID=8YFLogxK

U2 - 10.1023/A:1026537819055

DO - 10.1023/A:1026537819055

M3 - Article

C2 - 11142529

AN - SCOPUS:0034535907

VL - 11

SP - 941

EP - 954

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 10

ER -