An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease

Lidia Sarro; Nirubol Tosakulwong; Christopher G. Schwarz; Jonathan Graff-Radford; Scott A. Przybelski; Timothy G. Lesnick; Samantha M. Zuk; Robert I. Reid; Mekala R. Raman; Bradley F. Boeve; Tanis J. Ferman; David S. Knopman; Giancarlo Comi; Massimo Filippi; Melissa E. Murray; Joseph E. Parisi; Dennis W. Dickson; Ronald C. Petersen; Clifford R. Jack; Kejal Kantarci

doi:10.1016/j.jalz.2016.07.003

An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease

Lidia Sarro, Nirubol Tosakulwong, Christopher G. Schwarz, Jonathan Graff-Radford, Scott A. Przybelski, Timothy G. Lesnick, Samantha M. Zuk, Robert I. Reid, Mekala R. Raman, Bradley F. Boeve, Tanis J. Ferman, David S. Knopman, Giancarlo Comi, Massimo Filippi, Melissa E. Murray, Joseph E. Parisi, Dennis W. Dickson, Ronald C. Petersen, Clifford R. Jack, Kejal Kantarci

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Introduction Cerebrovascular lesions on MRI are common in Alzheimer's disease (AD) dementia, but less is known about their frequency and impact on dementia with Lewy bodies (DLB). Methods White-matter hyperintensities (WMHs) and infarcts on MRI were assessed in consecutive DLB (n = 81) and AD dementia (n = 240) patients and compared to age-matched and sex-matched cognitively normal subjects (CN) from a population-based cohort. Results DLB had higher WMH volume compared to CN, and WMH volume was higher in the occipital and posterior periventricular regions in DLB compared to AD. Higher WMH volume was associated with history of cardiovascular disease and diabetes but not with clinical disease severity in DLB. Frequency of infarcts in DLB was not different from CN and AD dementia. Discussion In DLB, WMH volume is higher than AD and CN and appears to be primarily associated with history of vascular disease.

Original language	English (US)
Pages (from-to)	257-266
Number of pages	10
Journal	Alzheimer's and Dementia
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/j.jalz.2016.07.003
State	Published - Mar 1 2017

Keywords

Alzheimer's disease
Cerebrovascular disease
Dementia with Lewy bodies
Infarcts
MRI
Sex differences
White matter hyperintensities

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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Sarro, L., Tosakulwong, N., Schwarz, C. G., Graff-Radford, J., Przybelski, S. A., Lesnick, T. G., Zuk, S. M., Reid, R. I., Raman, M. R., Boeve, B. F., Ferman, T. J., Knopman, D. S., Comi, G., Filippi, M., Murray, M. E., Parisi, J. E., Dickson, D. W., Petersen, R. C., Jack, C. R., & Kantarci, K. (2017). An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease. Alzheimer's and Dementia, 13(3), 257-266. https://doi.org/10.1016/j.jalz.2016.07.003

Sarro, L, Tosakulwong, N, Schwarz, CG , Graff-Radford, J, Przybelski, SA, Lesnick, TG, Zuk, SM, Reid, RI, Raman, MR, Boeve, BF , Ferman, TJ , Knopman, DS, Comi, G, Filippi, M, Murray, ME, Parisi, JE, Dickson, DW , Petersen, RC , Jack, CR & Kantarci, K 2017, 'An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease', Alzheimer's and Dementia, vol. 13, no. 3, pp. 257-266. https://doi.org/10.1016/j.jalz.2016.07.003

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abstract = "Introduction Cerebrovascular lesions on MRI are common in Alzheimer's disease (AD) dementia, but less is known about their frequency and impact on dementia with Lewy bodies (DLB). Methods White-matter hyperintensities (WMHs) and infarcts on MRI were assessed in consecutive DLB (n = 81) and AD dementia (n = 240) patients and compared to age-matched and sex-matched cognitively normal subjects (CN) from a population-based cohort. Results DLB had higher WMH volume compared to CN, and WMH volume was higher in the occipital and posterior periventricular regions in DLB compared to AD. Higher WMH volume was associated with history of cardiovascular disease and diabetes but not with clinical disease severity in DLB. Frequency of infarcts in DLB was not different from CN and AD dementia. Discussion In DLB, WMH volume is higher than AD and CN and appears to be primarily associated with history of vascular disease.",

keywords = "Alzheimer's disease, Cerebrovascular disease, Dementia with Lewy bodies, Infarcts, MRI, Sex differences, White matter hyperintensities",

author = "Lidia Sarro and Nirubol Tosakulwong and Schwarz, {Christopher G.} and Jonathan Graff-Radford and Przybelski, {Scott A.} and Lesnick, {Timothy G.} and Zuk, {Samantha M.} and Reid, {Robert I.} and Raman, {Mekala R.} and Boeve, {Bradley F.} and Ferman, {Tanis J.} and Knopman, {David S.} and Giancarlo Comi and Massimo Filippi and Murray, {Melissa E.} and Parisi, {Joseph E.} and Dickson, {Dennis W.} and Petersen, {Ronald C.} and Jack, {Clifford R.} and Kejal Kantarci",

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doi = "10.1016/j.jalz.2016.07.003",

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AU - Sarro, Lidia

AU - Tosakulwong, Nirubol

AU - Schwarz, Christopher G.

AU - Graff-Radford, Jonathan

AU - Przybelski, Scott A.

AU - Lesnick, Timothy G.

AU - Zuk, Samantha M.

AU - Reid, Robert I.

AU - Raman, Mekala R.

AU - Boeve, Bradley F.

AU - Ferman, Tanis J.

AU - Knopman, David S.

AU - Comi, Giancarlo

AU - Filippi, Massimo

AU - Murray, Melissa E.

AU - Parisi, Joseph E.

AU - Dickson, Dennis W.

AU - Petersen, Ronald C.

AU - Jack, Clifford R.

AU - Kantarci, Kejal

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Introduction Cerebrovascular lesions on MRI are common in Alzheimer's disease (AD) dementia, but less is known about their frequency and impact on dementia with Lewy bodies (DLB). Methods White-matter hyperintensities (WMHs) and infarcts on MRI were assessed in consecutive DLB (n = 81) and AD dementia (n = 240) patients and compared to age-matched and sex-matched cognitively normal subjects (CN) from a population-based cohort. Results DLB had higher WMH volume compared to CN, and WMH volume was higher in the occipital and posterior periventricular regions in DLB compared to AD. Higher WMH volume was associated with history of cardiovascular disease and diabetes but not with clinical disease severity in DLB. Frequency of infarcts in DLB was not different from CN and AD dementia. Discussion In DLB, WMH volume is higher than AD and CN and appears to be primarily associated with history of vascular disease.

AB - Introduction Cerebrovascular lesions on MRI are common in Alzheimer's disease (AD) dementia, but less is known about their frequency and impact on dementia with Lewy bodies (DLB). Methods White-matter hyperintensities (WMHs) and infarcts on MRI were assessed in consecutive DLB (n = 81) and AD dementia (n = 240) patients and compared to age-matched and sex-matched cognitively normal subjects (CN) from a population-based cohort. Results DLB had higher WMH volume compared to CN, and WMH volume was higher in the occipital and posterior periventricular regions in DLB compared to AD. Higher WMH volume was associated with history of cardiovascular disease and diabetes but not with clinical disease severity in DLB. Frequency of infarcts in DLB was not different from CN and AD dementia. Discussion In DLB, WMH volume is higher than AD and CN and appears to be primarily associated with history of vascular disease.

KW - Alzheimer's disease

KW - Cerebrovascular disease

KW - Dementia with Lewy bodies

KW - Infarcts

KW - MRI

KW - Sex differences

KW - White matter hyperintensities

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An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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