An architectural perspective of vitamin D responsiveness

Martin Montecino, Gary S. Stein, Fernando Cruzat, Sylvain Marcellini, Janet L. Stein, Jane B. Lian, Andre J. van Wijnen, Gloria Arriagada

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Vitamin D serves as a principal modulator of skeletal gene transcription, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiological responsiveness requires combinatorial control where coregulatory proteins determine the specificity of biological responsiveness to physiological cues. It is becoming increasingly evident that the regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.

Original languageEnglish (US)
Pages (from-to)293-299
Number of pages7
JournalArchives of Biochemistry and Biophysics
Volume460
Issue number2
DOIs
StatePublished - Apr 15 2007

Keywords

  • Bone
  • Chromatin
  • Nuclear architecture
  • Nuclear matrix
  • Transcription

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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    Montecino, M., Stein, G. S., Cruzat, F., Marcellini, S., Stein, J. L., Lian, J. B., van Wijnen, A. J., & Arriagada, G. (2007). An architectural perspective of vitamin D responsiveness. Archives of Biochemistry and Biophysics, 460(2), 293-299. https://doi.org/10.1016/j.abb.2006.12.015