Amyloid-Beta-Related Angiitis with Distinctive Neuro-Ophthalmologic Features

Oana M. Dumitrascu, Erin M. Okazaki, Steven Cobb, Matthew A. Zarka, Stephen A. De Souza, Gyanendra Kumar, Cumara B. O’Carroll

Research output: Contribution to journalArticle

Abstract

Amyloid beta-related angiitis (ABRA) is a subtype of cerebral amyloid angiopathy-related inflammation, with distinctive pathology and prognosis compared with cerebral amyloid angiopathy (CAA). On a spectrum of increasing severity, ABRA is considered to be in-between the less aggressive inflammatory-CAA and the more severe primary central nervous system (CNS) angiitis. Whereas retinal pathological changes were described in subjects with primary or secondary CNS angiitis, and non-inflammatory CAA, bilateral posterior pole superficial and peripapillary retinal hemorrhages have not been reported as initial signs in patients with pathology-confirmed ABRA, accompanying neurological spells and characteristic neuroimaging findings.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalNeuro-Ophthalmology
DOIs
StateAccepted/In press - Sep 17 2017

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Keywords

  • Amyloid angiopathy
  • inflammation
  • neuro-ophthalmology
  • retina

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

Cite this

Dumitrascu, O. M., Okazaki, E. M., Cobb, S., Zarka, M. A., De Souza, S. A., Kumar, G., & O’Carroll, C. B. (Accepted/In press). Amyloid-Beta-Related Angiitis with Distinctive Neuro-Ophthalmologic Features. Neuro-Ophthalmology, 1-5. https://doi.org/10.1080/01658107.2017.1374982