Abstract
The beta-site of β-amyloid precursor protein cleaving enzyme (BACE) cleaves the β-amyloid (Aβ) precursor protein at the N-terminal end of Aβ, allowing for the production of Aβ by C-terminal γ-secretase cleavage. We hypothesized that over-activity of BACE might lead to the overproduction of Aβ, hence causing Alzheimer's disease (AD). Molecular genetic analyses of BACE in 9 autosomal dominant AD families and a population-based sample of 101 presenile AD cases did not identify genetic linkage, pathogenic mutations or genetic association with BACE, suggesting that BACE is not genetically involved in the etiology of AD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 105-107 |
| Number of pages | 3 |
| Journal | Neuroscience Letters |
| Volume | 313 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Nov 2 2001 |
| Externally published | Yes |
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Keywords
- β-amyloid
- Alzheimer's disease
- BACE
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Amyloid β secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease. / Cruts, Marc; Dermaut, Bart; Rademakers, Rosa V; Roks, Gerwin; Van den Broeck, Marleen; Munteanu, Gabriela; Van Duijn, Cornelia M.; Van Broeckhoven, Christine.
In: Neuroscience Letters, Vol. 313, No. 1-2, 02.11.2001, p. 105-107.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Amyloid β secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease
AU - Cruts, Marc
AU - Dermaut, Bart
AU - Rademakers, Rosa V
AU - Roks, Gerwin
AU - Van den Broeck, Marleen
AU - Munteanu, Gabriela
AU - Van Duijn, Cornelia M.
AU - Van Broeckhoven, Christine
PY - 2001/11/2
Y1 - 2001/11/2
N2 - The beta-site of β-amyloid precursor protein cleaving enzyme (BACE) cleaves the β-amyloid (Aβ) precursor protein at the N-terminal end of Aβ, allowing for the production of Aβ by C-terminal γ-secretase cleavage. We hypothesized that over-activity of BACE might lead to the overproduction of Aβ, hence causing Alzheimer's disease (AD). Molecular genetic analyses of BACE in 9 autosomal dominant AD families and a population-based sample of 101 presenile AD cases did not identify genetic linkage, pathogenic mutations or genetic association with BACE, suggesting that BACE is not genetically involved in the etiology of AD.
AB - The beta-site of β-amyloid precursor protein cleaving enzyme (BACE) cleaves the β-amyloid (Aβ) precursor protein at the N-terminal end of Aβ, allowing for the production of Aβ by C-terminal γ-secretase cleavage. We hypothesized that over-activity of BACE might lead to the overproduction of Aβ, hence causing Alzheimer's disease (AD). Molecular genetic analyses of BACE in 9 autosomal dominant AD families and a population-based sample of 101 presenile AD cases did not identify genetic linkage, pathogenic mutations or genetic association with BACE, suggesting that BACE is not genetically involved in the etiology of AD.
KW - β-amyloid
KW - Alzheimer's disease
KW - BACE
UR - http://www.scopus.com/inward/record.url?scp=0035798269&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035798269&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(01)02234-0
DO - 10.1016/S0304-3940(01)02234-0
M3 - Article
C2 - 11684351
AN - SCOPUS:0035798269
VL - 313
SP - 105
EP - 107
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -