Amplification of the platelet-derived growth factor receptor-a (PDGFRA) gene occurs in oligodendrogliomas with grade IV anaplastic features

Justin S. Smith, Xiao Yang Wang, Junqi Qian, Sandra M. Hosek, Bernd W. Scheithauer, Robert B. Jenkins, C. David James

Research output: Contribution to journalArticle

109 Scopus citations

Abstract

Activation of the platelet-derived growth factor (PDGF) signaling system has been implicated the development and malignant progression of diffuse gliomas. Overexpression of PDGF system components, particularly the alpha subtype receptor (PDGFRA), is common in glial tumors, and PDGFRA gene amplification has been reported in glioblastomas. In order to address the incidence of PDGFRA gene amplification in a broad set of diffuse gliomas, we used Southern and fluorescence in situ hybridization (FISH) analyses to examine 167 astrocytic gliomas (20 grade III and 147 grade IV), 41 anaplastic oligodendrogliomas, and 29 anaplastic oligoastrocytomas. PDGFRA gene amplification was identified in 4 an aplastic oligodendrogliomas and in a single case of anaplastic oligoastrocytoma, but in none of the malignant astrocytomas. Each of the 5 tumors with PDGFRA amplification displayed features generally associated with grade IV malignancy in astrocytic tumors. Consequently, off, data indicate that this gene alteration is restricted to tumors having oligoclendroglial differentiation and highly anaplastic features.

Original languageEnglish (US)
Pages (from-to)495-503
Number of pages9
JournalJournal of Neuropathology and Experimental Neurology
Volume59
Issue number6
DOIs
StatePublished - Jun 2000

Keywords

  • Astrocytoma
  • FISH
  • Gene amplification
  • Oligodendroglioma
  • PDGFRA

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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