AMD3100 affects autograft lymphocyte collection and progression-free survival after autologous stem cell transplantion in non-Hodgkin lymphoma

Shernan G. Holtan, Luis F. Porrata, Ivana N.M. Micallef, Douglas J. Padley, David J. Inwards, Stephen A. Ansell, Patrick B. Johnston, Dennis A. Gastineau, Svetomir N. Markovic

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Purpose: Autograft absolute lymphocyte count (A-ALC) affects survival after autologous stem cell transplantation (ASCT) in non-Hodgkin lymphoma (NHL). AMD3100, a CXCR4 antagonist, mobilizes CD34+ stem cells in patients with NHL undergoing ASCT. We sought to study the impact of AMD3100 on A-ALC collection in patients with NHL undergoing ASCT. Patients and Methods: The primary endpoint of the study was to assess the association between AMD3100 and A-ALC collection. We compared 7 consecutive patients with NHL mobilized with AMD3100 and granulocyte colony-stimulating factor with 29 control patients with NHL mobilized with granulocyte colony-stimulating factor alone. Results: Higher median A-ALCs were observed in the AMD3100 group compared with the control group (4.16 × 109 lymphocytes/kg vs. 0.288 × 109 lymphocytes/kg; P < 0.0001). With a median follow-up of 20 months (range, 4-24 months), no relapses were reported in the AMD3100 group compared with 15 of 29 in the control group (P < 0.02). Conclusion: Our data suggest that AMD3100 affects A-ALC and clinical outcome in patients with NHL undergoing ASCT.

Original languageEnglish (US)
Pages (from-to)315-318
Number of pages4
JournalClinical Lymphoma and Myeloma
Volume7
Issue number4
DOIs
StatePublished - Jan 2007

Keywords

  • Autograft absolute lymphocyte count
  • Endpoint
  • Granulocyte colony-stimulating factor

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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