Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid β-protein

Medicine & Life Sciences

• Insulysin 100%
• Amyloidogenic Proteins 86%
• Alternative Splicing 70%
• Protein Isoforms 52%
• Insulin 43%
• Untranslated Regions 13%
• Exons 12%
• Amyloid beta-Protein Precursor 11%
• Mouse Ide protein 10%
• Mutation 8%
• Alzheimer disease type 2 7%
• Serum Amyloid A Protein 6%
• Genetic Linkage 6%
• Polyadenylation 6%
• Nucleic Acid Regulatory Sequences 5%
• Hyperinsulinism 5%
• Efficiency 5%
• Glucose Intolerance 5%
• Cytosol 4%
• Organelles 4%
• Confocal Microscopy 4%
• Electron Microscopy 4%
• Mitochondria 4%
• Alzheimer Disease 3%
• Type 2 Diabetes Mellitus 3%
• Kinetics 3%
• Aptitude 3%
• Messenger RNA 2%
• Brain 2%
• Genes 1%
• Proteins 1%

Chemical Compounds

• Insulin Derivative 65%
• Mutation 54%
• Km 26%
• Protein 26%
• Reaction Yield 26%
• Homodimer 24%
• Confocal Microscopy 24%
• Heterodimer 24%
• Fractionation 18%
• Glucose 15%