Altered sensitivity of the gallbladder to cholecystokinin octapeptide in irritable bowel syndrome

J. E. Kellow, Laurence J Miller, S. F. Phillips, A. R. Zinsmeister, J. W. Charboneau

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

We compared responses of the gallbladder to graded intravenous infusions of cholecystokinin octapeptide (CCK-OP) in normal controls (n = 8) and patients with irritable bowel syndrome (IBS) with predominant constipation (n = 8) or diarrhea (n = 8). The doses of CCK-OP ranged from subphysiological (negligible contraction of the gallbladder) to supraphysiological (90% contraction of gallbladder and abdominal side effects) amounts. All gallbladders contracted progressively in response to CCK-OP, and a Weibull model (power exponential function) described precisely the gallbladder's response to CCK-OP. Patients with IBS responded differently from normal patients; those with constipation contracted their gallbladders more and those with diarrhea contracted less in response to the peptide. Gallbladders were also stimulated with a high-fat, liquid meal; all patients' gallbladders contracted, but clear differences between groups could not be demonstrated postprandially. The results suggest that the smooth muscle of the gallbladder in IBS has an abnormal sensitivity to CCK-OP, and the results support the concept that IBS can be a generalized abnormality of the smooth muscle of the digestive tract.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume253
Issue number5
StatePublished - 1987
Externally publishedYes

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Sincalide
Irritable Bowel Syndrome
Gallbladder
Constipation
Smooth Muscle
Diarrhea
Intravenous Infusions
Meals
Gastrointestinal Tract
Fats
Peptides

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Altered sensitivity of the gallbladder to cholecystokinin octapeptide in irritable bowel syndrome. / Kellow, J. E.; Miller, Laurence J; Phillips, S. F.; Zinsmeister, A. R.; Charboneau, J. W.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 253, No. 5, 1987.

Research output: Contribution to journalArticle

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