Alterations of T-lymphocyte populations in Parkinson disease

Yasuhiko Baba, Ataru Kuroiwa, Ryan J. Uitti, Zbigniew K. Wszolek, Tatsuo Yamada

Research output: Contribution to journalArticlepeer-review

165 Scopus citations

Abstract

Immune reaction-related inflammation may be important in the pathogenesis of Parkinson disease (PD). To elucidate peripheral immunologic alterations in PD, we characterized extended peripheral T-lymphocyte populations in 33 patients with PD and 34 normal subjects. Patients with PD had significantly decreased CD4+:CD8+T-cell ratios (P<0.001), fewer CD4 +CD25+T cells (P<0.01), and significantly increased ratios of IFN-γ-producing to IL-4-producing T cells (P<0.001). The characteristics of predominant expression of CD8+T cells, depletion of CD4+CD25high cells, and a shift to a T H1-type immune response in the peripheral immune system in PD patients may reflect an immune reaction-associated inflammatory process in the brain.

Original languageEnglish (US)
Pages (from-to)493-498
Number of pages6
JournalParkinsonism and Related Disorders
Volume11
Issue number8
DOIs
StatePublished - Dec 1 2005

Keywords

  • Cytokine
  • Immunologic alteration
  • Parkinson disease
  • T lymphocyte

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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