Alterations of T-lymphocyte populations in Parkinson disease

Yasuhiko Baba; Ataru Kuroiwa; Ryan J. Uitti; Zbigniew K. Wszolek; Tatsuo Yamada

doi:10.1016/j.parkreldis.2005.07.005

Alterations of T-lymphocyte populations in Parkinson disease

Yasuhiko Baba, Ataru Kuroiwa, Ryan J. Uitti, Zbigniew K. Wszolek, Tatsuo Yamada

Neurology

Research output: Contribution to journal › Article › peer-review

178 Scopus citations

Abstract

Immune reaction-related inflammation may be important in the pathogenesis of Parkinson disease (PD). To elucidate peripheral immunologic alterations in PD, we characterized extended peripheral T-lymphocyte populations in 33 patients with PD and 34 normal subjects. Patients with PD had significantly decreased CD4⁺:CD8⁺T-cell ratios (P<0.001), fewer CD4 ⁺CD25⁺T cells (P<0.01), and significantly increased ratios of IFN-γ-producing to IL-4-producing T cells (P<0.001). The characteristics of predominant expression of CD8⁺T cells, depletion of CD4⁺CD25^high cells, and a shift to a T _H1-type immune response in the peripheral immune system in PD patients may reflect an immune reaction-associated inflammatory process in the brain.

Original language	English (US)
Pages (from-to)	493-498
Number of pages	6
Journal	Parkinsonism and Related Disorders
Volume	11
Issue number	8
DOIs	https://doi.org/10.1016/j.parkreldis.2005.07.005
State	Published - Dec 1 2005

Keywords

Cytokine
Immunologic alteration
Parkinson disease
T lymphocyte

ASJC Scopus subject areas

Neurology
Geriatrics and Gerontology
Clinical Neurology

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10.1016/j.parkreldis.2005.07.005

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abstract = "Immune reaction-related inflammation may be important in the pathogenesis of Parkinson disease (PD). To elucidate peripheral immunologic alterations in PD, we characterized extended peripheral T-lymphocyte populations in 33 patients with PD and 34 normal subjects. Patients with PD had significantly decreased CD4+:CD8+T-cell ratios (P<0.001), fewer CD4 +CD25+T cells (P<0.01), and significantly increased ratios of IFN-γ-producing to IL-4-producing T cells (P<0.001). The characteristics of predominant expression of CD8+T cells, depletion of CD4+CD25high cells, and a shift to a T H1-type immune response in the peripheral immune system in PD patients may reflect an immune reaction-associated inflammatory process in the brain.",

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AU - Baba, Yasuhiko

AU - Kuroiwa, Ataru

AU - Uitti, Ryan J.

AU - Wszolek, Zbigniew K.

AU - Yamada, Tatsuo

PY - 2005/12/1

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N2 - Immune reaction-related inflammation may be important in the pathogenesis of Parkinson disease (PD). To elucidate peripheral immunologic alterations in PD, we characterized extended peripheral T-lymphocyte populations in 33 patients with PD and 34 normal subjects. Patients with PD had significantly decreased CD4+:CD8+T-cell ratios (P<0.001), fewer CD4 +CD25+T cells (P<0.01), and significantly increased ratios of IFN-γ-producing to IL-4-producing T cells (P<0.001). The characteristics of predominant expression of CD8+T cells, depletion of CD4+CD25high cells, and a shift to a T H1-type immune response in the peripheral immune system in PD patients may reflect an immune reaction-associated inflammatory process in the brain.

AB - Immune reaction-related inflammation may be important in the pathogenesis of Parkinson disease (PD). To elucidate peripheral immunologic alterations in PD, we characterized extended peripheral T-lymphocyte populations in 33 patients with PD and 34 normal subjects. Patients with PD had significantly decreased CD4+:CD8+T-cell ratios (P<0.001), fewer CD4 +CD25+T cells (P<0.01), and significantly increased ratios of IFN-γ-producing to IL-4-producing T cells (P<0.001). The characteristics of predominant expression of CD8+T cells, depletion of CD4+CD25high cells, and a shift to a T H1-type immune response in the peripheral immune system in PD patients may reflect an immune reaction-associated inflammatory process in the brain.

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KW - T lymphocyte

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Alterations of T-lymphocyte populations in Parkinson disease

Abstract

Keywords

ASJC Scopus subject areas

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