Alterations in central hemodynamic in patients with COPD after acute high intensity exercise

M. Behnia, C. M. Wheatley-Guy, B. D. Johnson, A. Avolio, C. H. Kim

Research output: Contribution to journalArticle

Abstract

The present study investigated the relationship between central hemodynamics and lung function and the response to an acute bout of exercise in COPD. Methods: Based on the severity of COPD, moderate group (MOD, n = 12) and more mild group (MLD, n = 12) underwent central hemodynamic assessments pre- and post-peak exercise. Results: In the entire cohort (n = 24), central diastolic blood pressure (cDBP) was associated with pulmonary function. Post-exercise, cDBP remained elevated (p < 0.01), however, peripheral diastolic blood pressure (pDBP) was reduced (p = 0.02). Prior to exercise, the MOD showed higher cDBP and heart rate (HR) than the MLD (p = 0.02 and p = 0.01, respectively), but no difference in central aortic/arterial stiffness (p > 0.05). These findings remained similar post-exercise. Conclusion: Central diastolic blood pressure is linked to pulmonary function in COPD and it is elevated after exercise-induced reductions in pDBP. Central diastolic blood pressure is higher in the MOD than the MLD, however, there was no difference in central aortic/arterial stiffness between groups.

Original languageEnglish (US)
JournalPulmonology
DOIs
StateAccepted/In press - 2020

Keywords

  • Central aortic pressure
  • COPD
  • Lung function

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Alterations in central hemodynamic in patients with COPD after acute high intensity exercise'. Together they form a unique fingerprint.

  • Cite this