Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment

Fanny W.F. Shum, Long Jun Wu, Ming Gao Zhao, Hiroki Toyoda, Hui Xu, Ming Ren, Raphael Pinaud, Shanelle W. Ko, Yong Seok Lee, Bong Kiun Kaang, Min Zhuo

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25 Scopus citations

Abstract

Exposure to an enriched environment (EE) has been shown to induce cortical plasticity. Considerable amount of research is focused on the effects of EE in the hippocampus; however, effects of EE on other brain regions and the mechanisms involved are not well known. To investigate this, we induced cortical plasticity by placing mice in an EE for one month and measured the effects of EE in the anterior cingulate cortex (ACC). Here, we show that EE enhanced the expression of the plasticity gene, egr-1, in the ACC of EE animals accompanied by enhanced cingulate long-term potentiation (LTP) and decreased cingulate long-term depression (LTD). The increased NMDA receptor NR2B/NR2A subunits current ratio is associated with the plasticity seen in the ACC while total protein levels remain unchanged. Furthermore, behavioral experiments show that these mice exposed to EE demonstrate enhanced responses to acute and long-term inflammation. Our findings suggest that exposure to EE alters physiological properties within the ACC which results in enhanced responses to inflammation.

Original languageEnglish (US)
Pages (from-to)304-312
Number of pages9
JournalLearning and Memory
Volume14
Issue number4
DOIs
StatePublished - Apr 1 2007

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ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Shum, F. W. F., Wu, L. J., Zhao, M. G., Toyoda, H., Xu, H., Ren, M., Pinaud, R., Ko, S. W., Lee, Y. S., Kaang, B. K., & Zhuo, M. (2007). Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment. Learning and Memory, 14(4), 304-312. https://doi.org/10.1101/lm.530607