Abstract
In a previous study, alpha-1-antitrypsin (A1AT) deficiency alleles were found to be over represented among individuals with microsatellite unstable (MSI-high) colorectal cancers, and this was most significant in former or current smokers. We evaluated this association in a larger case-control study, stratified by microsatellite instability phenotypes. Concordant with prior observations, gender (female) and smoking history were positively associated with colorectal cancers having an MSI-high phenotype. No difference in frequency of A1AT deficiency alleles was found between cases and controls, irrespective of the MSI subtype.
Original language | English (US) |
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Pages (from-to) | 157-159 |
Number of pages | 3 |
Journal | Molecular genetics and metabolism |
Volume | 99 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2010 |
Keywords
- DNA mismatch repair
- Microsatellite instability
- Protease inhibitor
- Smoking
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Molecular Biology
- Genetics
- Endocrinology