Alcohol consumption and survival after a breast cancer diagnosis: A literature-based meta-analysis and collaborative analysis of data for 29,239 cases

Alaa M.G. Ali, Marjanka K. Schmidt, Manjeet K. Bolla, Qin Wang, M. Gago-Dominguez, J. Esteban Castelao, Angel Carracedo, Victor Muñoz Garzón, Stig E. Bojesen, Børge G. Nordestgaard, Henrik Flyger, Jenny Chang-Claude, Alina Vrieling, Anja Rudolph, Petra Seibold, Heli Nevanlinna, Taru A. Muranen, Kirsimari Aaltonen, Carl Blomqvist, Keitaro MatsuoHidemi Ito, Hiroji Iwata, Akiyo Horio, Esther M. John, Mark E. Sherman, Jolanta Lissowska, Jonine Figueroa, Montserrat Garcia-Closas, Hoda Anton-Culver, Mitul Shah, John L. Hopper, Antonia Trichopoulou, Bas Bueno-de-Mesquita, Vittorio Krogh, Elisabete Weiderpass, Anne Andersson, Françoise Clavel-Chapelon, Laure Dossus, Guy Fagherazzi, Petra H. Peeters, Anja Olsen, Gordon C. Wishart, Douglas F. Easton, Signe Borgquist, Kim Overvad, Aurelio Barricarte, Carlos A. González, María José Sánchez, Pilar Amiano, Elio Riboli, Tim Key, Paul D. Pharoah

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods: A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for "moderate drinkers" versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results: We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate post-diagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85-1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73-0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ERpositive disease, there was little evidence that pre- or postdiagnosis alcohol consumption is associated with breast cancer-specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer-specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. Conclusion: There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer-specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer - specific mortality in ER-negative disease. Impact: Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer.

Original languageEnglish (US)
Pages (from-to)934-945
Number of pages12
JournalCancer Epidemiology Biomarkers and Prevention
Volume23
Issue number6
DOIs
StatePublished - 2014

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Alcohol Drinking
Meta-Analysis
Estrogen Receptors
Breast Neoplasms
Survival
Mortality
Alcohols
Confidence Intervals
Cerebral Palsy
MEDLINE

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Alcohol consumption and survival after a breast cancer diagnosis : A literature-based meta-analysis and collaborative analysis of data for 29,239 cases. / Ali, Alaa M.G.; Schmidt, Marjanka K.; Bolla, Manjeet K.; Wang, Qin; Gago-Dominguez, M.; Esteban Castelao, J.; Carracedo, Angel; Garzón, Victor Muñoz; Bojesen, Stig E.; Nordestgaard, Børge G.; Flyger, Henrik; Chang-Claude, Jenny; Vrieling, Alina; Rudolph, Anja; Seibold, Petra; Nevanlinna, Heli; Muranen, Taru A.; Aaltonen, Kirsimari; Blomqvist, Carl; Matsuo, Keitaro; Ito, Hidemi; Iwata, Hiroji; Horio, Akiyo; John, Esther M.; Sherman, Mark E.; Lissowska, Jolanta; Figueroa, Jonine; Garcia-Closas, Montserrat; Anton-Culver, Hoda; Shah, Mitul; Hopper, John L.; Trichopoulou, Antonia; Bueno-de-Mesquita, Bas; Krogh, Vittorio; Weiderpass, Elisabete; Andersson, Anne; Clavel-Chapelon, Françoise; Dossus, Laure; Fagherazzi, Guy; Peeters, Petra H.; Olsen, Anja; Wishart, Gordon C.; Easton, Douglas F.; Borgquist, Signe; Overvad, Kim; Barricarte, Aurelio; González, Carlos A.; Sánchez, María José; Amiano, Pilar; Riboli, Elio; Key, Tim; Pharoah, Paul D.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 23, No. 6, 2014, p. 934-945.

Research output: Contribution to journalArticle

Ali, AMG, Schmidt, MK, Bolla, MK, Wang, Q, Gago-Dominguez, M, Esteban Castelao, J, Carracedo, A, Garzón, VM, Bojesen, SE, Nordestgaard, BG, Flyger, H, Chang-Claude, J, Vrieling, A, Rudolph, A, Seibold, P, Nevanlinna, H, Muranen, TA, Aaltonen, K, Blomqvist, C, Matsuo, K, Ito, H, Iwata, H, Horio, A, John, EM, Sherman, ME, Lissowska, J, Figueroa, J, Garcia-Closas, M, Anton-Culver, H, Shah, M, Hopper, JL, Trichopoulou, A, Bueno-de-Mesquita, B, Krogh, V, Weiderpass, E, Andersson, A, Clavel-Chapelon, F, Dossus, L, Fagherazzi, G, Peeters, PH, Olsen, A, Wishart, GC, Easton, DF, Borgquist, S, Overvad, K, Barricarte, A, González, CA, Sánchez, MJ, Amiano, P, Riboli, E, Key, T & Pharoah, PD 2014, 'Alcohol consumption and survival after a breast cancer diagnosis: A literature-based meta-analysis and collaborative analysis of data for 29,239 cases', Cancer Epidemiology Biomarkers and Prevention, vol. 23, no. 6, pp. 934-945. https://doi.org/10.1158/1055-9965.EPI-13-0901
Ali, Alaa M.G. ; Schmidt, Marjanka K. ; Bolla, Manjeet K. ; Wang, Qin ; Gago-Dominguez, M. ; Esteban Castelao, J. ; Carracedo, Angel ; Garzón, Victor Muñoz ; Bojesen, Stig E. ; Nordestgaard, Børge G. ; Flyger, Henrik ; Chang-Claude, Jenny ; Vrieling, Alina ; Rudolph, Anja ; Seibold, Petra ; Nevanlinna, Heli ; Muranen, Taru A. ; Aaltonen, Kirsimari ; Blomqvist, Carl ; Matsuo, Keitaro ; Ito, Hidemi ; Iwata, Hiroji ; Horio, Akiyo ; John, Esther M. ; Sherman, Mark E. ; Lissowska, Jolanta ; Figueroa, Jonine ; Garcia-Closas, Montserrat ; Anton-Culver, Hoda ; Shah, Mitul ; Hopper, John L. ; Trichopoulou, Antonia ; Bueno-de-Mesquita, Bas ; Krogh, Vittorio ; Weiderpass, Elisabete ; Andersson, Anne ; Clavel-Chapelon, Françoise ; Dossus, Laure ; Fagherazzi, Guy ; Peeters, Petra H. ; Olsen, Anja ; Wishart, Gordon C. ; Easton, Douglas F. ; Borgquist, Signe ; Overvad, Kim ; Barricarte, Aurelio ; González, Carlos A. ; Sánchez, María José ; Amiano, Pilar ; Riboli, Elio ; Key, Tim ; Pharoah, Paul D. / Alcohol consumption and survival after a breast cancer diagnosis : A literature-based meta-analysis and collaborative analysis of data for 29,239 cases. In: Cancer Epidemiology Biomarkers and Prevention. 2014 ; Vol. 23, No. 6. pp. 934-945.
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abstract = "Background: Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods: A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for {"}moderate drinkers{"} versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results: We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate post-diagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95{\%} confidence interval (CI), 0.85-1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95{\%} CI, 0.73-0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ERpositive disease, there was little evidence that pre- or postdiagnosis alcohol consumption is associated with breast cancer-specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer-specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. Conclusion: There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer-specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer - specific mortality in ER-negative disease. Impact: Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer.",
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TY - JOUR

T1 - Alcohol consumption and survival after a breast cancer diagnosis

T2 - A literature-based meta-analysis and collaborative analysis of data for 29,239 cases

AU - Ali, Alaa M.G.

AU - Schmidt, Marjanka K.

AU - Bolla, Manjeet K.

AU - Wang, Qin

AU - Gago-Dominguez, M.

AU - Esteban Castelao, J.

AU - Carracedo, Angel

AU - Garzón, Victor Muñoz

AU - Bojesen, Stig E.

AU - Nordestgaard, Børge G.

AU - Flyger, Henrik

AU - Chang-Claude, Jenny

AU - Vrieling, Alina

AU - Rudolph, Anja

AU - Seibold, Petra

AU - Nevanlinna, Heli

AU - Muranen, Taru A.

AU - Aaltonen, Kirsimari

AU - Blomqvist, Carl

AU - Matsuo, Keitaro

AU - Ito, Hidemi

AU - Iwata, Hiroji

AU - Horio, Akiyo

AU - John, Esther M.

AU - Sherman, Mark E.

AU - Lissowska, Jolanta

AU - Figueroa, Jonine

AU - Garcia-Closas, Montserrat

AU - Anton-Culver, Hoda

AU - Shah, Mitul

AU - Hopper, John L.

AU - Trichopoulou, Antonia

AU - Bueno-de-Mesquita, Bas

AU - Krogh, Vittorio

AU - Weiderpass, Elisabete

AU - Andersson, Anne

AU - Clavel-Chapelon, Françoise

AU - Dossus, Laure

AU - Fagherazzi, Guy

AU - Peeters, Petra H.

AU - Olsen, Anja

AU - Wishart, Gordon C.

AU - Easton, Douglas F.

AU - Borgquist, Signe

AU - Overvad, Kim

AU - Barricarte, Aurelio

AU - González, Carlos A.

AU - Sánchez, María José

AU - Amiano, Pilar

AU - Riboli, Elio

AU - Key, Tim

AU - Pharoah, Paul D.

PY - 2014

Y1 - 2014

N2 - Background: Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods: A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for "moderate drinkers" versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results: We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate post-diagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85-1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73-0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ERpositive disease, there was little evidence that pre- or postdiagnosis alcohol consumption is associated with breast cancer-specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer-specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. Conclusion: There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer-specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer - specific mortality in ER-negative disease. Impact: Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer.

AB - Background: Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods: A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for "moderate drinkers" versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results: We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate post-diagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85-1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73-0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ERpositive disease, there was little evidence that pre- or postdiagnosis alcohol consumption is associated with breast cancer-specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer-specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. Conclusion: There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer-specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer - specific mortality in ER-negative disease. Impact: Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer.

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