Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus

Mi Hyeon Jang; Min Chul Shin; Sae Bin Jung; Taeck Hyun Lee; Geon Ho Bahn; Yunhee Kim Kwon; Ee Hwa Kim; Chang Ju Kim

doi:10.1097/00001756-200208270-00004

Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus

Mi Hyeon Jang, Min Chul Shin, Sae Bin Jung, Taeck Hyun Lee, Geon Ho Bahn, Yunhee Kim Kwon, Ee Hwa Kim, Chang Ju Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

It is generally accepted that alcohol and nicotine affect learning ability and memory functions, especially in adolescents. In the present study, the effects of alcohol and nicotine on cell proliferation and apoptosis in the dentate gyrus of young rats were investigated. The results show that cell proliferation is suppressed by alcohol and nicotine. Furthermore, alcohol and nicotine increase the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive cells. Based on the results presented in this study, it can be suggested that alcohol- and nicotine-related impairment in learning and memory functions may be due to alcohol- and nicotine-induced suppression of new cell formation and acceleration of apoptosis, especially during adolescence.

Original language	English (US)
Pages (from-to)	1509-1513
Number of pages	5
Journal	NeuroReport
Volume	13
Issue number	12
DOIs	https://doi.org/10.1097/00001756-200208270-00004
State	Published - Aug 27 2002

Keywords

5 -Bromo-2′-deoxyuridine (BrdU)
Alcohol
Immunohistochemistry
Nicotine
Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1097/00001756-200208270-00004

Cite this

@article{0dd56eea5b944cc4b8c6865d264ed6c0,

title = "Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus",

abstract = "It is generally accepted that alcohol and nicotine affect learning ability and memory functions, especially in adolescents. In the present study, the effects of alcohol and nicotine on cell proliferation and apoptosis in the dentate gyrus of young rats were investigated. The results show that cell proliferation is suppressed by alcohol and nicotine. Furthermore, alcohol and nicotine increase the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive cells. Based on the results presented in this study, it can be suggested that alcohol- and nicotine-related impairment in learning and memory functions may be due to alcohol- and nicotine-induced suppression of new cell formation and acceleration of apoptosis, especially during adolescence.",

keywords = "5 -Bromo-2′-deoxyuridine (BrdU), Alcohol, Immunohistochemistry, Nicotine, Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay",

author = "Jang, {Mi Hyeon} and Shin, {Min Chul} and Jung, {Sae Bin} and Lee, {Taeck Hyun} and Bahn, {Geon Ho} and Kwon, {Yunhee Kim} and Kim, {Ee Hwa} and Kim, {Chang Ju}",

year = "2002",

month = aug,

day = "27",

doi = "10.1097/00001756-200208270-00004",

language = "English (US)",

volume = "13",

pages = "1509--1513",

journal = "NeuroReport",

issn = "0959-4965",

publisher = "Lippincott Williams and Wilkins",

number = "12",

}

TY - JOUR

T1 - Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus

AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Jung, Sae Bin

AU - Lee, Taeck Hyun

AU - Bahn, Geon Ho

AU - Kwon, Yunhee Kim

AU - Kim, Ee Hwa

AU - Kim, Chang Ju

PY - 2002/8/27

Y1 - 2002/8/27

N2 - It is generally accepted that alcohol and nicotine affect learning ability and memory functions, especially in adolescents. In the present study, the effects of alcohol and nicotine on cell proliferation and apoptosis in the dentate gyrus of young rats were investigated. The results show that cell proliferation is suppressed by alcohol and nicotine. Furthermore, alcohol and nicotine increase the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive cells. Based on the results presented in this study, it can be suggested that alcohol- and nicotine-related impairment in learning and memory functions may be due to alcohol- and nicotine-induced suppression of new cell formation and acceleration of apoptosis, especially during adolescence.

AB - It is generally accepted that alcohol and nicotine affect learning ability and memory functions, especially in adolescents. In the present study, the effects of alcohol and nicotine on cell proliferation and apoptosis in the dentate gyrus of young rats were investigated. The results show that cell proliferation is suppressed by alcohol and nicotine. Furthermore, alcohol and nicotine increase the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive cells. Based on the results presented in this study, it can be suggested that alcohol- and nicotine-related impairment in learning and memory functions may be due to alcohol- and nicotine-induced suppression of new cell formation and acceleration of apoptosis, especially during adolescence.

KW - 5 -Bromo-2′-deoxyuridine (BrdU)

KW - Alcohol

KW - Immunohistochemistry

KW - Nicotine

KW - Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay

UR - http://www.scopus.com/inward/record.url?scp=0037183566&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037183566&partnerID=8YFLogxK

U2 - 10.1097/00001756-200208270-00004

DO - 10.1097/00001756-200208270-00004

M3 - Article

C2 - 12218695

AN - SCOPUS:0037183566

SN - 0959-4965

VL - 13

SP - 1509

EP - 1513

JO - NeuroReport

JF - NeuroReport

IS - 12

ER -

Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this