Airway Innervation and Plasticity in Asthma

L. E.M. Kistemaker, Y. S. Prakash

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Airway nerves represent a mechanistically and therapeutically important aspectthat requires better highlighting in the context of diseases such asasthma. Altered structure and function (plasticity) of afferent and efferentairway innervation can contribute to airway diseases. We describe establishedanatomy, current understanding of how plasticity occurs, and contributions ofplasticity to asthma, focusing on target-derived growth factors (neurotrophins).Perspectives toward novel treatment strategies and future research are provided.

Original languageEnglish (US)
Pages (from-to)283-298
Number of pages16
JournalPhysiology
Volume34
Issue number4
DOIs
StatePublished - Jul 2019

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ASJC Scopus subject areas

  • Physiology

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