Airway Innervation and Plasticity in Asthma

L. E.M. Kistemaker; Y. S. Prakash

doi:10.1152/physiol.00050.2018

Airway Innervation and Plasticity in Asthma

L. E.M. Kistemaker, Y. S. Prakash

Anesthesiology

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Airway nerves represent a mechanistically and therapeutically important aspectthat requires better highlighting in the context of diseases such asasthma. Altered structure and function (plasticity) of afferent and efferentairway innervation can contribute to airway diseases. We describe establishedanatomy, current understanding of how plasticity occurs, and contributions ofplasticity to asthma, focusing on target-derived growth factors (neurotrophins).Perspectives toward novel treatment strategies and future research are provided.

Original language	English (US)
Pages (from-to)	283-298
Number of pages	16
Journal	Physiology
Volume	34
Issue number	4
DOIs	https://doi.org/10.1152/physiol.00050.2018
State	Published - Jul 2019

ASJC Scopus subject areas

Physiology

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10.1152/physiol.00050.2018

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AB - Airway nerves represent a mechanistically and therapeutically important aspectthat requires better highlighting in the context of diseases such asasthma. Altered structure and function (plasticity) of afferent and efferentairway innervation can contribute to airway diseases. We describe establishedanatomy, current understanding of how plasticity occurs, and contributions ofplasticity to asthma, focusing on target-derived growth factors (neurotrophins).Perspectives toward novel treatment strategies and future research are provided.

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Airway Innervation and Plasticity in Asthma

Abstract

ASJC Scopus subject areas

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