Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial phenomenon?

Emilia J. Sitek, Ewa Narozanska, Anna Barczak, Barbara Jasinska-Myga, Michał Harciarek, Małgorzata Chodakowska-Zebrowska, Małgorzata Kubiak, Dariusz Wieczorek, Seweryna Konieczna, Rosa Rademakers, Matt Baker, Mariusz Berdynski, Bogna Brockhuis, Maria Barcikowska, Cezary Zekanowski, Kenneth M. Heilman, Zbigniew K. Wszolek, Jarosław Slawek

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Objectives: Patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) may be agraphic. The study aimed at characterizing agraphia in individuals with a P301L MAPT mutation.Methods: Two pairs of siblings with FTDP-17 were longitudinally examined for agraphia in relation to language and cognitive deficits.Results: All patients presented with dysexecutive agraphia. In addition, in the first pair of siblings one sibling demonstrated spatial agraphia with less pronounced allographic agraphia and the other sibling had aphasic agraphia. Aphasic agraphia was also present in one sibling from the second pair.Conclusion: Agraphia associated with FTDP-17 is very heterogeneous.

Original languageEnglish (US)
Pages (from-to)69-86
Number of pages18
JournalNeurocase
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Aphasic agraphia
  • Dysexecutive agraphia
  • Frontotemporal dementia
  • Neuropsychological assessment
  • Spatial agraphia
  • Writing

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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    Sitek, E. J., Narozanska, E., Barczak, A., Jasinska-Myga, B., Harciarek, M., Chodakowska-Zebrowska, M., Kubiak, M., Wieczorek, D., Konieczna, S., Rademakers, R., Baker, M., Berdynski, M., Brockhuis, B., Barcikowska, M., Zekanowski, C., Heilman, K. M., Wszolek, Z. K., & Slawek, J. (2014). Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial phenomenon? Neurocase, 20(1), 69-86. https://doi.org/10.1080/13554794.2012.732087