Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial phenomenon?

Emilia J. Sitek, Ewa Narozanska, Anna Barczak, Barbara Jasinska-Myga, Michał Harciarek, Małgorzata Chodakowska-Zebrowska, Małgorzata Kubiak, Dariusz Wieczorek, Seweryna Konieczna, Rosa V Rademakers, Matt Baker, Mariusz Berdynski, Bogna Brockhuis, Maria Barcikowska, Cezary Zekanowski, Kenneth M. Heilman, Zbigniew K Wszolek, Jarosław Slawek

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives: Patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) may be agraphic. The study aimed at characterizing agraphia in individuals with a P301L MAPT mutation.Methods: Two pairs of siblings with FTDP-17 were longitudinally examined for agraphia in relation to language and cognitive deficits.Results: All patients presented with dysexecutive agraphia. In addition, in the first pair of siblings one sibling demonstrated spatial agraphia with less pronounced allographic agraphia and the other sibling had aphasic agraphia. Aphasic agraphia was also present in one sibling from the second pair.Conclusion: Agraphia associated with FTDP-17 is very heterogeneous.

Original languageEnglish (US)
Pages (from-to)69-86
Number of pages18
JournalNeurocase
Volume20
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Agraphia
Frontotemporal Dementia
Chromosomes, Human, Pair 17
Mutation
Siblings
Aphasic
Chromosome
Language

Keywords

  • Aphasic agraphia
  • Dysexecutive agraphia
  • Frontotemporal dementia
  • Neuropsychological assessment
  • Spatial agraphia
  • Writing

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation : dysexecutive, aphasic, apraxic or spatial phenomenon? / Sitek, Emilia J.; Narozanska, Ewa; Barczak, Anna; Jasinska-Myga, Barbara; Harciarek, Michał; Chodakowska-Zebrowska, Małgorzata; Kubiak, Małgorzata; Wieczorek, Dariusz; Konieczna, Seweryna; Rademakers, Rosa V; Baker, Matt; Berdynski, Mariusz; Brockhuis, Bogna; Barcikowska, Maria; Zekanowski, Cezary; Heilman, Kenneth M.; Wszolek, Zbigniew K; Slawek, Jarosław.

In: Neurocase, Vol. 20, No. 1, 01.2014, p. 69-86.

Research output: Contribution to journalArticle

Sitek, EJ, Narozanska, E, Barczak, A, Jasinska-Myga, B, Harciarek, M, Chodakowska-Zebrowska, M, Kubiak, M, Wieczorek, D, Konieczna, S, Rademakers, RV, Baker, M, Berdynski, M, Brockhuis, B, Barcikowska, M, Zekanowski, C, Heilman, KM, Wszolek, ZK & Slawek, J 2014, 'Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial phenomenon?', Neurocase, vol. 20, no. 1, pp. 69-86. https://doi.org/10.1080/13554794.2012.732087
Sitek, Emilia J. ; Narozanska, Ewa ; Barczak, Anna ; Jasinska-Myga, Barbara ; Harciarek, Michał ; Chodakowska-Zebrowska, Małgorzata ; Kubiak, Małgorzata ; Wieczorek, Dariusz ; Konieczna, Seweryna ; Rademakers, Rosa V ; Baker, Matt ; Berdynski, Mariusz ; Brockhuis, Bogna ; Barcikowska, Maria ; Zekanowski, Cezary ; Heilman, Kenneth M. ; Wszolek, Zbigniew K ; Slawek, Jarosław. / Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation : dysexecutive, aphasic, apraxic or spatial phenomenon?. In: Neurocase. 2014 ; Vol. 20, No. 1. pp. 69-86.
@article{c17aa69655f54d2d812c3017bd92b639,
title = "Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial phenomenon?",
abstract = "Objectives: Patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) may be agraphic. The study aimed at characterizing agraphia in individuals with a P301L MAPT mutation.Methods: Two pairs of siblings with FTDP-17 were longitudinally examined for agraphia in relation to language and cognitive deficits.Results: All patients presented with dysexecutive agraphia. In addition, in the first pair of siblings one sibling demonstrated spatial agraphia with less pronounced allographic agraphia and the other sibling had aphasic agraphia. Aphasic agraphia was also present in one sibling from the second pair.Conclusion: Agraphia associated with FTDP-17 is very heterogeneous.",
keywords = "Aphasic agraphia, Dysexecutive agraphia, Frontotemporal dementia, Neuropsychological assessment, Spatial agraphia, Writing",
author = "Sitek, {Emilia J.} and Ewa Narozanska and Anna Barczak and Barbara Jasinska-Myga and Michał Harciarek and Małgorzata Chodakowska-Zebrowska and Małgorzata Kubiak and Dariusz Wieczorek and Seweryna Konieczna and Rademakers, {Rosa V} and Matt Baker and Mariusz Berdynski and Bogna Brockhuis and Maria Barcikowska and Cezary Zekanowski and Heilman, {Kenneth M.} and Wszolek, {Zbigniew K} and Jarosław Slawek",
year = "2014",
month = "1",
doi = "10.1080/13554794.2012.732087",
language = "English (US)",
volume = "20",
pages = "69--86",
journal = "Neurocase",
issn = "1355-4794",
publisher = "Psychology Press Ltd",
number = "1",

}

TY - JOUR

T1 - Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation

T2 - dysexecutive, aphasic, apraxic or spatial phenomenon?

AU - Sitek, Emilia J.

AU - Narozanska, Ewa

AU - Barczak, Anna

AU - Jasinska-Myga, Barbara

AU - Harciarek, Michał

AU - Chodakowska-Zebrowska, Małgorzata

AU - Kubiak, Małgorzata

AU - Wieczorek, Dariusz

AU - Konieczna, Seweryna

AU - Rademakers, Rosa V

AU - Baker, Matt

AU - Berdynski, Mariusz

AU - Brockhuis, Bogna

AU - Barcikowska, Maria

AU - Zekanowski, Cezary

AU - Heilman, Kenneth M.

AU - Wszolek, Zbigniew K

AU - Slawek, Jarosław

PY - 2014/1

Y1 - 2014/1

N2 - Objectives: Patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) may be agraphic. The study aimed at characterizing agraphia in individuals with a P301L MAPT mutation.Methods: Two pairs of siblings with FTDP-17 were longitudinally examined for agraphia in relation to language and cognitive deficits.Results: All patients presented with dysexecutive agraphia. In addition, in the first pair of siblings one sibling demonstrated spatial agraphia with less pronounced allographic agraphia and the other sibling had aphasic agraphia. Aphasic agraphia was also present in one sibling from the second pair.Conclusion: Agraphia associated with FTDP-17 is very heterogeneous.

AB - Objectives: Patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) may be agraphic. The study aimed at characterizing agraphia in individuals with a P301L MAPT mutation.Methods: Two pairs of siblings with FTDP-17 were longitudinally examined for agraphia in relation to language and cognitive deficits.Results: All patients presented with dysexecutive agraphia. In addition, in the first pair of siblings one sibling demonstrated spatial agraphia with less pronounced allographic agraphia and the other sibling had aphasic agraphia. Aphasic agraphia was also present in one sibling from the second pair.Conclusion: Agraphia associated with FTDP-17 is very heterogeneous.

KW - Aphasic agraphia

KW - Dysexecutive agraphia

KW - Frontotemporal dementia

KW - Neuropsychological assessment

KW - Spatial agraphia

KW - Writing

UR - http://www.scopus.com/inward/record.url?scp=84889249948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84889249948&partnerID=8YFLogxK

U2 - 10.1080/13554794.2012.732087

DO - 10.1080/13554794.2012.732087

M3 - Article

C2 - 23121543

AN - SCOPUS:84889249948

VL - 20

SP - 69

EP - 86

JO - Neurocase

JF - Neurocase

SN - 1355-4794

IS - 1

ER -