TY - JOUR
T1 - Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation
T2 - dysexecutive, aphasic, apraxic or spatial phenomenon?
AU - Sitek, Emilia J.
AU - Narozanska, Ewa
AU - Barczak, Anna
AU - Jasinska-Myga, Barbara
AU - Harciarek, Michał
AU - Chodakowska-Zebrowska, Małgorzata
AU - Kubiak, Małgorzata
AU - Wieczorek, Dariusz
AU - Konieczna, Seweryna
AU - Rademakers, Rosa
AU - Baker, Matt
AU - Berdynski, Mariusz
AU - Brockhuis, Bogna
AU - Barcikowska, Maria
AU - Zekanowski, Cezary
AU - Heilman, Kenneth M.
AU - Wszolek, Zbigniew K.
AU - Slawek, Jarosław
PY - 2014/1
Y1 - 2014/1
N2 - Objectives: Patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) may be agraphic. The study aimed at characterizing agraphia in individuals with a P301L MAPT mutation.Methods: Two pairs of siblings with FTDP-17 were longitudinally examined for agraphia in relation to language and cognitive deficits.Results: All patients presented with dysexecutive agraphia. In addition, in the first pair of siblings one sibling demonstrated spatial agraphia with less pronounced allographic agraphia and the other sibling had aphasic agraphia. Aphasic agraphia was also present in one sibling from the second pair.Conclusion: Agraphia associated with FTDP-17 is very heterogeneous.
AB - Objectives: Patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) may be agraphic. The study aimed at characterizing agraphia in individuals with a P301L MAPT mutation.Methods: Two pairs of siblings with FTDP-17 were longitudinally examined for agraphia in relation to language and cognitive deficits.Results: All patients presented with dysexecutive agraphia. In addition, in the first pair of siblings one sibling demonstrated spatial agraphia with less pronounced allographic agraphia and the other sibling had aphasic agraphia. Aphasic agraphia was also present in one sibling from the second pair.Conclusion: Agraphia associated with FTDP-17 is very heterogeneous.
KW - Aphasic agraphia
KW - Dysexecutive agraphia
KW - Frontotemporal dementia
KW - Neuropsychological assessment
KW - Spatial agraphia
KW - Writing
UR - http://www.scopus.com/inward/record.url?scp=84889249948&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84889249948&partnerID=8YFLogxK
U2 - 10.1080/13554794.2012.732087
DO - 10.1080/13554794.2012.732087
M3 - Article
C2 - 23121543
AN - SCOPUS:84889249948
SN - 1355-4794
VL - 20
SP - 69
EP - 86
JO - Neurocase
JF - Neurocase
IS - 1
ER -