Age-related memory decline and apolipoprotein E e4.

Richard J. Caselli

Age-related memory decline and apolipoprotein E e4.

Richard J. Caselli

Neurology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The APOE epsilon4 allele is associated with risk of late-onset Alzheimer's disease (AD). Longitudinal memory decline in asymptomatic APOE epsilon4 carriers shows greater acceleration compared with non-carriers, with a possible allele-dose effect, and begins prior to age 60. These results correlate with imaging and neuropathological studies that show AD-like changes at this age and collectively support the existence of a presymptomatic stage of AD.

Original language	English (US)
Pages (from-to)	47-50
Number of pages	4
Journal	Discovery Medicine
Volume	8
Issue number	41
State	Published - Aug 2009

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Age-related memory decline and apolipoprotein E e4.",

abstract = "The APOE epsilon4 allele is associated with risk of late-onset Alzheimer's disease (AD). Longitudinal memory decline in asymptomatic APOE epsilon4 carriers shows greater acceleration compared with non-carriers, with a possible allele-dose effect, and begins prior to age 60. These results correlate with imaging and neuropathological studies that show AD-like changes at this age and collectively support the existence of a presymptomatic stage of AD.",

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AB - The APOE epsilon4 allele is associated with risk of late-onset Alzheimer's disease (AD). Longitudinal memory decline in asymptomatic APOE epsilon4 carriers shows greater acceleration compared with non-carriers, with a possible allele-dose effect, and begins prior to age 60. These results correlate with imaging and neuropathological studies that show AD-like changes at this age and collectively support the existence of a presymptomatic stage of AD.

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Age-related memory decline and apolipoprotein E e4.

Abstract

ASJC Scopus subject areas

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