Age-associated plasma lipids, lipid peroxidation, and antioxidant systems in relation to vitamin C supplementation in humans

M. Jayachandran, P. Arivazhagan, C. Panneerselvam

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

It is hypothesized that a reduction in the level of ascorbic acid with age leads to an impairment in the quenching of free radicals by antioxidants, which in turn increases the risk of succumbing to age-associated disorders. Healthy volunteers of both sexes at different age group were selected from the geriatric community. They were subjected to vitamin C supplementation. Lipids, lipid peroxidation, enzymatic, and nonenzymatic antioxidant status were gauged at the end of 30, 60, and 90 days. The activities/levels of enzymatic and nonenzymatic antioxidants were found to be low in the aged humans, whereas the lipid peroxidation status was found to be high. Supplementation of vitamin C lowered the levels of lipid peroxides, cholesterol, triacylglycerol, and phospholipids and increased the activities of enzymatic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase in the geriatric population. A substantial rise in the levels of nonenzymatic antioxidants such as vitamins C, E, and A were also observed but no significant alterations were noticed in the levels of bilirubin and uric acid. From our observations, we conclude that ascorbic acid normalizes lipid peroxidation and partially restores the antioxidant status. Thus ascorbate supplementation could be beneficial in minimizing age-associated disorders where free radicals are the major cause.

Original languageEnglish (US)
Pages (from-to)437-445
Number of pages9
JournalJournal of Anti-Aging Medicine
Volume3
Issue number4
StatePublished - 2000
Externally publishedYes

Fingerprint

Lipid Peroxidation
Ascorbic Acid
Antioxidants
Lipids
Geriatrics
Free Radicals
Glutathione Reductase
Lipid Peroxides
Glutathione Peroxidase
Uric Acid
Glutathione Transferase
Vitamin A
Vitamin E
Bilirubin
Catalase
Superoxide Dismutase
Phospholipids
Healthy Volunteers
Triglycerides
Age Groups

ASJC Scopus subject areas

  • Aging

Cite this

Age-associated plasma lipids, lipid peroxidation, and antioxidant systems in relation to vitamin C supplementation in humans. / Jayachandran, M.; Arivazhagan, P.; Panneerselvam, C.

In: Journal of Anti-Aging Medicine, Vol. 3, No. 4, 2000, p. 437-445.

Research output: Contribution to journalArticle

@article{96bda6ecf3c84daaad98cb6b6d0943e3,
title = "Age-associated plasma lipids, lipid peroxidation, and antioxidant systems in relation to vitamin C supplementation in humans",
abstract = "It is hypothesized that a reduction in the level of ascorbic acid with age leads to an impairment in the quenching of free radicals by antioxidants, which in turn increases the risk of succumbing to age-associated disorders. Healthy volunteers of both sexes at different age group were selected from the geriatric community. They were subjected to vitamin C supplementation. Lipids, lipid peroxidation, enzymatic, and nonenzymatic antioxidant status were gauged at the end of 30, 60, and 90 days. The activities/levels of enzymatic and nonenzymatic antioxidants were found to be low in the aged humans, whereas the lipid peroxidation status was found to be high. Supplementation of vitamin C lowered the levels of lipid peroxides, cholesterol, triacylglycerol, and phospholipids and increased the activities of enzymatic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase in the geriatric population. A substantial rise in the levels of nonenzymatic antioxidants such as vitamins C, E, and A were also observed but no significant alterations were noticed in the levels of bilirubin and uric acid. From our observations, we conclude that ascorbic acid normalizes lipid peroxidation and partially restores the antioxidant status. Thus ascorbate supplementation could be beneficial in minimizing age-associated disorders where free radicals are the major cause.",
author = "M. Jayachandran and P. Arivazhagan and C. Panneerselvam",
year = "2000",
language = "English (US)",
volume = "3",
pages = "437--445",
journal = "Rejuvenation Research",
issn = "1549-1684",
publisher = "Mary Ann Liebert Inc.",
number = "4",

}

TY - JOUR

T1 - Age-associated plasma lipids, lipid peroxidation, and antioxidant systems in relation to vitamin C supplementation in humans

AU - Jayachandran, M.

AU - Arivazhagan, P.

AU - Panneerselvam, C.

PY - 2000

Y1 - 2000

N2 - It is hypothesized that a reduction in the level of ascorbic acid with age leads to an impairment in the quenching of free radicals by antioxidants, which in turn increases the risk of succumbing to age-associated disorders. Healthy volunteers of both sexes at different age group were selected from the geriatric community. They were subjected to vitamin C supplementation. Lipids, lipid peroxidation, enzymatic, and nonenzymatic antioxidant status were gauged at the end of 30, 60, and 90 days. The activities/levels of enzymatic and nonenzymatic antioxidants were found to be low in the aged humans, whereas the lipid peroxidation status was found to be high. Supplementation of vitamin C lowered the levels of lipid peroxides, cholesterol, triacylglycerol, and phospholipids and increased the activities of enzymatic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase in the geriatric population. A substantial rise in the levels of nonenzymatic antioxidants such as vitamins C, E, and A were also observed but no significant alterations were noticed in the levels of bilirubin and uric acid. From our observations, we conclude that ascorbic acid normalizes lipid peroxidation and partially restores the antioxidant status. Thus ascorbate supplementation could be beneficial in minimizing age-associated disorders where free radicals are the major cause.

AB - It is hypothesized that a reduction in the level of ascorbic acid with age leads to an impairment in the quenching of free radicals by antioxidants, which in turn increases the risk of succumbing to age-associated disorders. Healthy volunteers of both sexes at different age group were selected from the geriatric community. They were subjected to vitamin C supplementation. Lipids, lipid peroxidation, enzymatic, and nonenzymatic antioxidant status were gauged at the end of 30, 60, and 90 days. The activities/levels of enzymatic and nonenzymatic antioxidants were found to be low in the aged humans, whereas the lipid peroxidation status was found to be high. Supplementation of vitamin C lowered the levels of lipid peroxides, cholesterol, triacylglycerol, and phospholipids and increased the activities of enzymatic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase in the geriatric population. A substantial rise in the levels of nonenzymatic antioxidants such as vitamins C, E, and A were also observed but no significant alterations were noticed in the levels of bilirubin and uric acid. From our observations, we conclude that ascorbic acid normalizes lipid peroxidation and partially restores the antioxidant status. Thus ascorbate supplementation could be beneficial in minimizing age-associated disorders where free radicals are the major cause.

UR - http://www.scopus.com/inward/record.url?scp=0034496428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034496428&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0034496428

VL - 3

SP - 437

EP - 445

JO - Rejuvenation Research

JF - Rejuvenation Research

SN - 1549-1684

IS - 4

ER -