African-American ethnicity is associated with higher plasma levels of D-dimer in adults with hypertension

M. Khaleghi, U. Saleem, R. D. McBane, T. H. Mosley, Iftikhar Jan Kullo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: African Americans with hypertension have higher cardiovascular morbidity and mortality than hypertensives from other ethnic groups. Plasma D-dimer, a fragment generated from fibrin during lysis of mature clot in vivo, is a predictor of adverse cardiovascular events. Objective: We investigated whether plasma levels of D-dimer differ between African American (AA) and non-Hispanic white (NHW) adults with hypertension. Methods: Participants included 933 AA (65 ± 9 years, 72% women) and 821 NHW (61 ± 9 years, 56% women) from the community. D-dimer was measured using an immunoturbidimetric assay. Multivariable regression analyses, stratified by gender, were performed to assess whether AA ethnicity was associated with D-dimer levels after adjustment for age, body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, systolic blood pressure, diabetes, history of smoking, medication (statin and aspirin) use, lifestyle variables (physical activity, alcohol intake, and education), estimated glomerular filtration rate (eGFR), and a marker of inflammation, C-reactive protein (CRP). Results: D-dimer levels were higher in AA men and women than in their NHW counterparts (mean ± SD; men 256 ± 199 vs. 190 ± 183 ng mL-1, P < 0.001; women, 290 ± 233 vs. 225 ± 195 ng mL-1, P < 0.001). In both sexes, after adjustment for age, conventional risk factors, medication use, and lifestyle variables, AA ethnicity remained associated with higher D-dimer levels (P = 0.002 in men, P = 0.006 in women). These associations remained significant after additional adjustment for eGFR and plasma CRP (P = 0.003 in men, P < 0.0001 in women). Conclusions: Among adults with hypertension, AA ethnicity was independently associated with higher plasma levels of D-dimer.

Original languageEnglish (US)
Pages (from-to)34-40
Number of pages7
JournalJournal of Thrombosis and Haemostasis
Volume7
Issue number1
DOIs
StatePublished - 2009

Fingerprint

African Americans
Hypertension
Glomerular Filtration Rate
C-Reactive Protein
Life Style
Blood Pressure
Hydroxymethylglutaryl-CoA Reductase Inhibitors
fibrin fragment D
Fibrin
Ethnic Groups
HDL Cholesterol
Aspirin
Blood Proteins
Body Mass Index
Smoking
Regression Analysis
Alcohols
Exercise
Inflammation
Morbidity

Keywords

  • D-dimer
  • Ethnicity
  • Hypertension
  • Risk factors

ASJC Scopus subject areas

  • Hematology

Cite this

African-American ethnicity is associated with higher plasma levels of D-dimer in adults with hypertension. / Khaleghi, M.; Saleem, U.; McBane, R. D.; Mosley, T. H.; Kullo, Iftikhar Jan.

In: Journal of Thrombosis and Haemostasis, Vol. 7, No. 1, 2009, p. 34-40.

Research output: Contribution to journalArticle

@article{8a44a0609f1f4801b7e0ef8becb856a3,
title = "African-American ethnicity is associated with higher plasma levels of D-dimer in adults with hypertension",
abstract = "Background: African Americans with hypertension have higher cardiovascular morbidity and mortality than hypertensives from other ethnic groups. Plasma D-dimer, a fragment generated from fibrin during lysis of mature clot in vivo, is a predictor of adverse cardiovascular events. Objective: We investigated whether plasma levels of D-dimer differ between African American (AA) and non-Hispanic white (NHW) adults with hypertension. Methods: Participants included 933 AA (65 ± 9 years, 72{\%} women) and 821 NHW (61 ± 9 years, 56{\%} women) from the community. D-dimer was measured using an immunoturbidimetric assay. Multivariable regression analyses, stratified by gender, were performed to assess whether AA ethnicity was associated with D-dimer levels after adjustment for age, body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, systolic blood pressure, diabetes, history of smoking, medication (statin and aspirin) use, lifestyle variables (physical activity, alcohol intake, and education), estimated glomerular filtration rate (eGFR), and a marker of inflammation, C-reactive protein (CRP). Results: D-dimer levels were higher in AA men and women than in their NHW counterparts (mean ± SD; men 256 ± 199 vs. 190 ± 183 ng mL-1, P < 0.001; women, 290 ± 233 vs. 225 ± 195 ng mL-1, P < 0.001). In both sexes, after adjustment for age, conventional risk factors, medication use, and lifestyle variables, AA ethnicity remained associated with higher D-dimer levels (P = 0.002 in men, P = 0.006 in women). These associations remained significant after additional adjustment for eGFR and plasma CRP (P = 0.003 in men, P < 0.0001 in women). Conclusions: Among adults with hypertension, AA ethnicity was independently associated with higher plasma levels of D-dimer.",
keywords = "D-dimer, Ethnicity, Hypertension, Risk factors",
author = "M. Khaleghi and U. Saleem and McBane, {R. D.} and Mosley, {T. H.} and Kullo, {Iftikhar Jan}",
year = "2009",
doi = "10.1111/j.1538-7836.2008.03215.x",
language = "English (US)",
volume = "7",
pages = "34--40",
journal = "Journal of Thrombosis and Haemostasis",
issn = "1538-7933",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - African-American ethnicity is associated with higher plasma levels of D-dimer in adults with hypertension

AU - Khaleghi, M.

AU - Saleem, U.

AU - McBane, R. D.

AU - Mosley, T. H.

AU - Kullo, Iftikhar Jan

PY - 2009

Y1 - 2009

N2 - Background: African Americans with hypertension have higher cardiovascular morbidity and mortality than hypertensives from other ethnic groups. Plasma D-dimer, a fragment generated from fibrin during lysis of mature clot in vivo, is a predictor of adverse cardiovascular events. Objective: We investigated whether plasma levels of D-dimer differ between African American (AA) and non-Hispanic white (NHW) adults with hypertension. Methods: Participants included 933 AA (65 ± 9 years, 72% women) and 821 NHW (61 ± 9 years, 56% women) from the community. D-dimer was measured using an immunoturbidimetric assay. Multivariable regression analyses, stratified by gender, were performed to assess whether AA ethnicity was associated with D-dimer levels after adjustment for age, body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, systolic blood pressure, diabetes, history of smoking, medication (statin and aspirin) use, lifestyle variables (physical activity, alcohol intake, and education), estimated glomerular filtration rate (eGFR), and a marker of inflammation, C-reactive protein (CRP). Results: D-dimer levels were higher in AA men and women than in their NHW counterparts (mean ± SD; men 256 ± 199 vs. 190 ± 183 ng mL-1, P < 0.001; women, 290 ± 233 vs. 225 ± 195 ng mL-1, P < 0.001). In both sexes, after adjustment for age, conventional risk factors, medication use, and lifestyle variables, AA ethnicity remained associated with higher D-dimer levels (P = 0.002 in men, P = 0.006 in women). These associations remained significant after additional adjustment for eGFR and plasma CRP (P = 0.003 in men, P < 0.0001 in women). Conclusions: Among adults with hypertension, AA ethnicity was independently associated with higher plasma levels of D-dimer.

AB - Background: African Americans with hypertension have higher cardiovascular morbidity and mortality than hypertensives from other ethnic groups. Plasma D-dimer, a fragment generated from fibrin during lysis of mature clot in vivo, is a predictor of adverse cardiovascular events. Objective: We investigated whether plasma levels of D-dimer differ between African American (AA) and non-Hispanic white (NHW) adults with hypertension. Methods: Participants included 933 AA (65 ± 9 years, 72% women) and 821 NHW (61 ± 9 years, 56% women) from the community. D-dimer was measured using an immunoturbidimetric assay. Multivariable regression analyses, stratified by gender, were performed to assess whether AA ethnicity was associated with D-dimer levels after adjustment for age, body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, systolic blood pressure, diabetes, history of smoking, medication (statin and aspirin) use, lifestyle variables (physical activity, alcohol intake, and education), estimated glomerular filtration rate (eGFR), and a marker of inflammation, C-reactive protein (CRP). Results: D-dimer levels were higher in AA men and women than in their NHW counterparts (mean ± SD; men 256 ± 199 vs. 190 ± 183 ng mL-1, P < 0.001; women, 290 ± 233 vs. 225 ± 195 ng mL-1, P < 0.001). In both sexes, after adjustment for age, conventional risk factors, medication use, and lifestyle variables, AA ethnicity remained associated with higher D-dimer levels (P = 0.002 in men, P = 0.006 in women). These associations remained significant after additional adjustment for eGFR and plasma CRP (P = 0.003 in men, P < 0.0001 in women). Conclusions: Among adults with hypertension, AA ethnicity was independently associated with higher plasma levels of D-dimer.

KW - D-dimer

KW - Ethnicity

KW - Hypertension

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=57749189371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57749189371&partnerID=8YFLogxK

U2 - 10.1111/j.1538-7836.2008.03215.x

DO - 10.1111/j.1538-7836.2008.03215.x

M3 - Article

C2 - 18983495

AN - SCOPUS:57749189371

VL - 7

SP - 34

EP - 40

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

SN - 1538-7933

IS - 1

ER -