Abstract
Enveloped viruses trigger membrane fusion to gain entry into cells. The receptor affinities of their attachment proteins vary greatly, from 10 -4 M to 10-9 M, but the significance of this is unknown. Using six retargeted measles viruses that bind to Her-2/neu with a 5-log range in affinity, we show that receptor affinity has little impact on viral attachment but is nevertheless a key determinant of infectivity and intercellular fusion. For a given cell surface receptor density, there is an affinity threshold above which cell-cell fusion proceeds efficiently. Suprathreshold affinities do not further enhance the efficiency of membrane fusion.
Original language | English (US) |
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Pages (from-to) | 13149-13157 |
Number of pages | 9 |
Journal | Journal of virology |
Volume | 81 |
Issue number | 23 |
DOIs | |
State | Published - Dec 2007 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology