Advances in the understanding of IgM monoclonal gammopathy of undetermined significance

Jonas Paludo, Stephen Maxted Ansell

Research output: Contribution to journalReview article

Abstract

Among monoclonal gammopathies of undetermined significance (MGUSs), the immunoglobulin M (IgM) MGUS subtype stands as a unique entity and plays a pivotal role as a pre-malignant condition for multiple B-cell non-Hodgkin lymphomas, most notably Waldenström macroglobulinemia (WM). A relationship between IgM MGUS and WM has been proposed for decades. However, insight regarding the pathobiology of these two conditions improved significantly in recent years, strengthening the hypothesis that WM and IgM MGUS are different stages of the same disease. Therefore, the understanding of IgM MGUS and that of WM are interconnected and advances in one will likely impact the other. Furthermore, IgM MGUS has been more commonly recognized as the underlying etiology of IgM-related disorders. In this review, we explore recent advances in the understanding of the pathobiology of IgM MGUS and WM and the treatment of common IgM-related disorders.

Original languageEnglish (US)
Article number2142
JournalF1000Research
Volume6
DOIs
StatePublished - Jan 1 2017

Fingerprint

Monoclonal Gammopathy of Undetermined Significance
Immunoglobulin M
Waldenstrom Macroglobulinemia
B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Cells

Keywords

  • IgM gammopathy
  • MGUS
  • Waldenstrom macroglobulinemia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Advances in the understanding of IgM monoclonal gammopathy of undetermined significance. / Paludo, Jonas; Ansell, Stephen Maxted.

In: F1000Research, Vol. 6, 2142, 01.01.2017.

Research output: Contribution to journalReview article

@article{4b96992bfa5b4b0487d478638ecb3899,
title = "Advances in the understanding of IgM monoclonal gammopathy of undetermined significance",
abstract = "Among monoclonal gammopathies of undetermined significance (MGUSs), the immunoglobulin M (IgM) MGUS subtype stands as a unique entity and plays a pivotal role as a pre-malignant condition for multiple B-cell non-Hodgkin lymphomas, most notably Waldenstr{\"o}m macroglobulinemia (WM). A relationship between IgM MGUS and WM has been proposed for decades. However, insight regarding the pathobiology of these two conditions improved significantly in recent years, strengthening the hypothesis that WM and IgM MGUS are different stages of the same disease. Therefore, the understanding of IgM MGUS and that of WM are interconnected and advances in one will likely impact the other. Furthermore, IgM MGUS has been more commonly recognized as the underlying etiology of IgM-related disorders. In this review, we explore recent advances in the understanding of the pathobiology of IgM MGUS and WM and the treatment of common IgM-related disorders.",
keywords = "IgM gammopathy, MGUS, Waldenstrom macroglobulinemia",
author = "Jonas Paludo and Ansell, {Stephen Maxted}",
year = "2017",
month = "1",
day = "1",
doi = "10.12688/f1000research.12880.1",
language = "English (US)",
volume = "6",
journal = "F1000Research",
issn = "2046-1402",
publisher = "F1000 Research Ltd.",

}

TY - JOUR

T1 - Advances in the understanding of IgM monoclonal gammopathy of undetermined significance

AU - Paludo, Jonas

AU - Ansell, Stephen Maxted

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Among monoclonal gammopathies of undetermined significance (MGUSs), the immunoglobulin M (IgM) MGUS subtype stands as a unique entity and plays a pivotal role as a pre-malignant condition for multiple B-cell non-Hodgkin lymphomas, most notably Waldenström macroglobulinemia (WM). A relationship between IgM MGUS and WM has been proposed for decades. However, insight regarding the pathobiology of these two conditions improved significantly in recent years, strengthening the hypothesis that WM and IgM MGUS are different stages of the same disease. Therefore, the understanding of IgM MGUS and that of WM are interconnected and advances in one will likely impact the other. Furthermore, IgM MGUS has been more commonly recognized as the underlying etiology of IgM-related disorders. In this review, we explore recent advances in the understanding of the pathobiology of IgM MGUS and WM and the treatment of common IgM-related disorders.

AB - Among monoclonal gammopathies of undetermined significance (MGUSs), the immunoglobulin M (IgM) MGUS subtype stands as a unique entity and plays a pivotal role as a pre-malignant condition for multiple B-cell non-Hodgkin lymphomas, most notably Waldenström macroglobulinemia (WM). A relationship between IgM MGUS and WM has been proposed for decades. However, insight regarding the pathobiology of these two conditions improved significantly in recent years, strengthening the hypothesis that WM and IgM MGUS are different stages of the same disease. Therefore, the understanding of IgM MGUS and that of WM are interconnected and advances in one will likely impact the other. Furthermore, IgM MGUS has been more commonly recognized as the underlying etiology of IgM-related disorders. In this review, we explore recent advances in the understanding of the pathobiology of IgM MGUS and WM and the treatment of common IgM-related disorders.

KW - IgM gammopathy

KW - MGUS

KW - Waldenstrom macroglobulinemia

UR - http://www.scopus.com/inward/record.url?scp=85041722407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041722407&partnerID=8YFLogxK

U2 - 10.12688/f1000research.12880.1

DO - 10.12688/f1000research.12880.1

M3 - Review article

VL - 6

JO - F1000Research

JF - F1000Research

SN - 2046-1402

M1 - 2142

ER -