Advances in radiofrequency ablation of the cerebral cortex in primates using the venous system: Improvements for treating epilepsy with catheter ablation technology

Benhur D. Henz; Paul A. Friedman; Charles J. Bruce; David R. Holmes; Mark Bower; Malini Madhavan; Christopher V. DeSimone; Douglas Wahnschaffe; Steven Berhow; Andrew J. Danielsen; Dorothy J. Ladewig; Susan B. Mikell; Susan B. Johnson; Scott H. Suddendorf; Tomas Kara; Gregory A. Worrell; Samuel J. Asirvatham

doi:10.1016/j.eplepsyres.2014.04.002

Advances in radiofrequency ablation of the cerebral cortex in primates using the venous system: Improvements for treating epilepsy with catheter ablation technology

Benhur D. Henz, Paul A. Friedman, Charles J. Bruce, David R. Holmes, Mark Bower, Malini Madhavan, Christopher V. DeSimone, Douglas Wahnschaffe, Steven Berhow, Andrew J. Danielsen, Dorothy J. Ladewig, Susan B. Mikell, Susan B. Johnson, Scott H. Suddendorf, Tomas Kara, Gregory A. Worrell, Samuel J. Asirvatham

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Pharmacology frequently fails for the treatment of epilepsy. Although surgical techniques are effective, these procedures are highly invasive. We describe feasibility and efficacy of minimally invasive mapping and ablation for the treatment of epilepsy. Methods: Mapping and radiofrequency ablations were performed via the venous system in eleven baboons and three dogs. Results: Mapping in deep cerebral areas was obtained in all animals. High-frequency pacing was able to induce seizure activity of local cerebral tissue in 72% of our attempts. Cerebral activity could be seen during mapping. Ablative lesions were deployed at deep brain sites without steam pops or sudden impedance rise. Histologic analysis showed necrosis at the sites of ablation in all primates. Conclusion: Navigation through the cerebral venous system to map seizure activity is feasible. Radiofrequency energy can be delivered transvenously or transcortically to successfully ablate cortical tissue in this animal model using this innovative approach.

Original language	English (US)
Pages (from-to)	1026-1031
Number of pages	6
Journal	Epilepsy Research
Volume	108
Issue number	6
DOIs	https://doi.org/10.1016/j.eplepsyres.2014.04.002
State	Published - Aug 2014

Keywords

Catheter ablation
Cerebral cortex
Epilepsy
Radiofrequency
Venous system

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1016/j.eplepsyres.2014.04.002

Cite this

Henz, B. D., Friedman, P. A., Bruce, C. J., Holmes, D. R., Bower, M., Madhavan, M., DeSimone, C. V., Wahnschaffe, D., Berhow, S., Danielsen, A. J., Ladewig, D. J., Mikell, S. B., Johnson, S. B., Suddendorf, S. H., Kara, T., Worrell, G. A., & Asirvatham, S. J. (2014). Advances in radiofrequency ablation of the cerebral cortex in primates using the venous system: Improvements for treating epilepsy with catheter ablation technology. Epilepsy Research, 108(6), 1026-1031. https://doi.org/10.1016/j.eplepsyres.2014.04.002

Henz, BD, Friedman, PA , Bruce, CJ , Holmes, DR, Bower, M, Madhavan, M, DeSimone, CV, Wahnschaffe, D, Berhow, S, Danielsen, AJ, Ladewig, DJ, Mikell, SB, Johnson, SB, Suddendorf, SH, Kara, T, Worrell, GA & Asirvatham, SJ 2014, 'Advances in radiofrequency ablation of the cerebral cortex in primates using the venous system: Improvements for treating epilepsy with catheter ablation technology', Epilepsy Research, vol. 108, no. 6, pp. 1026-1031. https://doi.org/10.1016/j.eplepsyres.2014.04.002

@article{49708af7d9b54482a49756579bd3db52,

title = "Advances in radiofrequency ablation of the cerebral cortex in primates using the venous system: Improvements for treating epilepsy with catheter ablation technology",

abstract = "Background: Pharmacology frequently fails for the treatment of epilepsy. Although surgical techniques are effective, these procedures are highly invasive. We describe feasibility and efficacy of minimally invasive mapping and ablation for the treatment of epilepsy. Methods: Mapping and radiofrequency ablations were performed via the venous system in eleven baboons and three dogs. Results: Mapping in deep cerebral areas was obtained in all animals. High-frequency pacing was able to induce seizure activity of local cerebral tissue in 72% of our attempts. Cerebral activity could be seen during mapping. Ablative lesions were deployed at deep brain sites without steam pops or sudden impedance rise. Histologic analysis showed necrosis at the sites of ablation in all primates. Conclusion: Navigation through the cerebral venous system to map seizure activity is feasible. Radiofrequency energy can be delivered transvenously or transcortically to successfully ablate cortical tissue in this animal model using this innovative approach.",

keywords = "Catheter ablation, Cerebral cortex, Epilepsy, Radiofrequency, Venous system",

author = "Henz, {Benhur D.} and Friedman, {Paul A.} and Bruce, {Charles J.} and Holmes, {David R.} and Mark Bower and Malini Madhavan and DeSimone, {Christopher V.} and Douglas Wahnschaffe and Steven Berhow and Danielsen, {Andrew J.} and Ladewig, {Dorothy J.} and Mikell, {Susan B.} and Johnson, {Susan B.} and Suddendorf, {Scott H.} and Tomas Kara and Worrell, {Gregory A.} and Asirvatham, {Samuel J.}",

note = "Funding Information: SJA and TK were supported by the European Regional Development Fund – Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123 ). ",

year = "2014",

month = aug,

doi = "10.1016/j.eplepsyres.2014.04.002",

language = "English (US)",

volume = "108",

pages = "1026--1031",

journal = "Epilepsy Research",

issn = "0920-1211",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Advances in radiofrequency ablation of the cerebral cortex in primates using the venous system

T2 - Improvements for treating epilepsy with catheter ablation technology

AU - Henz, Benhur D.

AU - Friedman, Paul A.

AU - Bruce, Charles J.

AU - Holmes, David R.

AU - Bower, Mark

AU - Madhavan, Malini

AU - DeSimone, Christopher V.

AU - Wahnschaffe, Douglas

AU - Berhow, Steven

AU - Danielsen, Andrew J.

AU - Ladewig, Dorothy J.

AU - Mikell, Susan B.

AU - Johnson, Susan B.

AU - Suddendorf, Scott H.

AU - Kara, Tomas

AU - Worrell, Gregory A.

AU - Asirvatham, Samuel J.

N1 - Funding Information: SJA and TK were supported by the European Regional Development Fund – Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123 ).

PY - 2014/8

Y1 - 2014/8

N2 - Background: Pharmacology frequently fails for the treatment of epilepsy. Although surgical techniques are effective, these procedures are highly invasive. We describe feasibility and efficacy of minimally invasive mapping and ablation for the treatment of epilepsy. Methods: Mapping and radiofrequency ablations were performed via the venous system in eleven baboons and three dogs. Results: Mapping in deep cerebral areas was obtained in all animals. High-frequency pacing was able to induce seizure activity of local cerebral tissue in 72% of our attempts. Cerebral activity could be seen during mapping. Ablative lesions were deployed at deep brain sites without steam pops or sudden impedance rise. Histologic analysis showed necrosis at the sites of ablation in all primates. Conclusion: Navigation through the cerebral venous system to map seizure activity is feasible. Radiofrequency energy can be delivered transvenously or transcortically to successfully ablate cortical tissue in this animal model using this innovative approach.

AB - Background: Pharmacology frequently fails for the treatment of epilepsy. Although surgical techniques are effective, these procedures are highly invasive. We describe feasibility and efficacy of minimally invasive mapping and ablation for the treatment of epilepsy. Methods: Mapping and radiofrequency ablations were performed via the venous system in eleven baboons and three dogs. Results: Mapping in deep cerebral areas was obtained in all animals. High-frequency pacing was able to induce seizure activity of local cerebral tissue in 72% of our attempts. Cerebral activity could be seen during mapping. Ablative lesions were deployed at deep brain sites without steam pops or sudden impedance rise. Histologic analysis showed necrosis at the sites of ablation in all primates. Conclusion: Navigation through the cerebral venous system to map seizure activity is feasible. Radiofrequency energy can be delivered transvenously or transcortically to successfully ablate cortical tissue in this animal model using this innovative approach.

KW - Catheter ablation

KW - Cerebral cortex

KW - Epilepsy

KW - Radiofrequency

KW - Venous system

UR - http://www.scopus.com/inward/record.url?scp=84902283701&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902283701&partnerID=8YFLogxK

U2 - 10.1016/j.eplepsyres.2014.04.002

DO - 10.1016/j.eplepsyres.2014.04.002

M3 - Article

C2 - 24836846

AN - SCOPUS:84902283701

SN - 0920-1211

VL - 108

SP - 1026

EP - 1031

JO - Epilepsy Research

JF - Epilepsy Research

IS - 6

ER -

Advances in radiofrequency ablation of the cerebral cortex in primates using the venous system: Improvements for treating epilepsy with catheter ablation technology

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this