Advances in Nanotechnology-Based Drug Delivery Platforms and Novel Drug Delivery Systems

Krishna Suri, Joy Wolfram, Haifa Shen, Mauro Ferrari

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

The human body has a multitude of physiological barriers that must be overcome for systemic delivery of a drug to a target region. Because these barriers are each of a different nature, a multifaceted approach to drug delivery should prove advantageous. Nanotechnology enables the design of multifunctional delivery vehicles that can penetrate biological obstacles. To date, four major design strategies have been utilized to obtain preferential accumulation of nanoparticles: (1) biophysical targeting, (2) molecular targeting, (3) use of biomaterials, and (4) use of external energy. Furthermore, the emergence of next-generation nanoparticles that incorporate nanomaterials that can be activated in a time-sequential manner offers promising tools for medical applications.

Original languageEnglish (US)
Title of host publicationNovel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies
PublisherElsevier Inc.
Pages41-58
Number of pages18
ISBN (Electronic)9780124166615
ISBN (Print)9780124166035
DOIs
StatePublished - Jan 5 2015

Keywords

  • Biological barriers
  • Drug delivery
  • Nanomedicine
  • Nanotechnology
  • Nanotherapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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