Adult bone marrow-derived cells for cardiac repair: A systematic review and meta-analysis

Ahmed Abdel-Latif, Roberto Bolli, Imad M. Tleyjeh, Victor M. Montori, Emerson C. Perin, Carlton A. Hornung, Ewa K. Zuba-Surma, Mouaz Al-Mallah, Buddhadeb Dawn

Research output: Contribution to journalReview article

786 Scopus citations

Abstract

Background: The results from small clinical studies suggest that therapy with adult bone marrow (BM)-derived cells (BMCs) reduces infarct size and improves left ventricular function and perfusion. However, the effects of BMC transplantation in patients with ischemic heart disease remains unclear. Methods: We searched MEDLINE, EMBASE, Science Citation Index, CINAHL (Cumulative Index to Nursing and Allied Health), and the Cochrane Central Register of Controlled Trials (CENTRAL) (through July 2006) for randomized controlled trials and cohort studies of BMC transplantation to treat ischemic heart disease. We conducted a random-effects meta-analysis across eligible studies measuring the same outcomes. Results: Eighteen studies (N=999 patients) were eligible. The adult BMCs included BM mononuclear cells, BM mesenchymal stem cells, and BM-derived circulating progenitor cells. Compared with controls, BMC transplantation improved left ventricular ejection fraction (pooled difference, 3.66%; 95% confidence interval [CI], 1.93% to 5.40%; P<.001); reduced infarct scar size (?5.49%; 95% CI, ?9.10% to ?1.88%; P=.003); and reduced left ventricular end-systolic volume (?4.80 mL; 95% CI, ?8.20 to ?1.41 mL; P=.006). Conclusions: The available evidence suggests that BMC transplantation is associated with modest improvements in physiologic and anatomic parameters in patients with both acute myocardial infarction and chronic ischemic heart disease, above and beyond conventional therapy. Therapy with BMCs seems safe. These results support conducting large randomized trials to evaluate the impact of BMC therapy vs the standard of care on patient-important outcomes.

Original languageEnglish (US)
Pages (from-to)989-997
Number of pages9
JournalArchives of internal medicine
Volume167
Issue number10
DOIs
StatePublished - May 28 2007

ASJC Scopus subject areas

  • Internal Medicine

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    Abdel-Latif, A., Bolli, R., Tleyjeh, I. M., Montori, V. M., Perin, E. C., Hornung, C. A., Zuba-Surma, E. K., Al-Mallah, M., & Dawn, B. (2007). Adult bone marrow-derived cells for cardiac repair: A systematic review and meta-analysis. Archives of internal medicine, 167(10), 989-997. https://doi.org/10.1001/archinte.167.10.989