Adsorption of 99mTc-sestamibi onto plastic syringes: Evaluation of factors affecting the degree of adsorption and their impact on clinical studies

Tiffinee N. Swanson, Duong T. Troung, Andrew Paulsen, Carrie B. Hruska, Michael K. O'Connor

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The purpose of this study was to document the extent of adhesion of 99mTc-sestamibi to syringes in patient procedures,determine factors that influence the degree of adhesion, and evaluate alternatives to our current practice that would either result in a more reproducible degree of adhesion or, ideally, eliminate adhesion. Methods: The extent of adhesion was documented in 216 patient procedures and evaluated in detail in an additional 73 patient procedures. We evaluated the nature of the adhesion and its possible causes, including the location of adhesion in injection sets, the effect of syringe type, and the effect of prerinsing of syringes with various solutions of nonradiolabeled sestamibi and 99mTc-sestamibi. The extent of adhesion was reevaluated in 50 procedures performed using the syringe type that demonstrated the lowest adhesion rate. Results: The degree of adhesion of 99mTc-sestamibi to the injection set was found to be 20.1% 6 8.0%, with a range (10th- 90th percentiles) of 9%-31%. The primary cause of adhesion appeared to be the lubricant used inside the syringe barrel. Evaluation of 6 different syringe types identified a brand with a lower adhesion rate. Reevaluation in patient procedures using this brand showed a 5.2% 6 2.5% degree of adhesion, with a range (10th-90th percentiles) of 2.5%-7.7%. Conclusion: Selection of the appropriate type of syringe can significantly reduce the magnitude and variability of residual 99mTc-sestamibi activity. With more reproducible residual activities, we have been able to achieve an approximately 20% reduction in the dispensed dose of 99mTc-sestamibi used in clinical procedures and a more consistent injected dose with less interpatient variation. The frequent changes in syringe design by manufacturers require that a quality control program for monitoring of residual activity be incorporated into clinical practice. This program has allowed us to maintain image quality and achieve more consistent injected patient doses in clinical procedures that use 99mTc-sestamibi.

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalJournal of nuclear medicine technology
Volume41
Issue number4
DOIs
StatePublished - Dec 1 2013

Keywords

  • Adhesion
  • Adsorption
  • Tc-sestamibi
  • plastic syringe

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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