Adsorption of 99mTc-sestamibi onto plastic syringes: Evaluation of factors affecting the degree of adsorption and their impact on clinical studies

Tiffinee N. Swanson, Duong T. Troung, Andrew Paulsen, Carrie B Hruska, Michael K. O'Connor

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The purpose of this study was to document the extent of adhesion of 99mTc-sestamibi to syringes in patient procedures,determine factors that influence the degree of adhesion, and evaluate alternatives to our current practice that would either result in a more reproducible degree of adhesion or, ideally, eliminate adhesion. Methods: The extent of adhesion was documented in 216 patient procedures and evaluated in detail in an additional 73 patient procedures. We evaluated the nature of the adhesion and its possible causes, including the location of adhesion in injection sets, the effect of syringe type, and the effect of prerinsing of syringes with various solutions of nonradiolabeled sestamibi and 99mTc-sestamibi. The extent of adhesion was reevaluated in 50 procedures performed using the syringe type that demonstrated the lowest adhesion rate. Results: The degree of adhesion of 99mTc-sestamibi to the injection set was found to be 20.1% 6 8.0%, with a range (10th- 90th percentiles) of 9%-31%. The primary cause of adhesion appeared to be the lubricant used inside the syringe barrel. Evaluation of 6 different syringe types identified a brand with a lower adhesion rate. Reevaluation in patient procedures using this brand showed a 5.2% 6 2.5% degree of adhesion, with a range (10th-90th percentiles) of 2.5%-7.7%. Conclusion: Selection of the appropriate type of syringe can significantly reduce the magnitude and variability of residual 99mTc-sestamibi activity. With more reproducible residual activities, we have been able to achieve an approximately 20% reduction in the dispensed dose of 99mTc-sestamibi used in clinical procedures and a more consistent injected dose with less interpatient variation. The frequent changes in syringe design by manufacturers require that a quality control program for monitoring of residual activity be incorporated into clinical practice. This program has allowed us to maintain image quality and achieve more consistent injected patient doses in clinical procedures that use 99mTc-sestamibi.

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalJournal of Nuclear Medicine Technology
Volume41
Issue number4
DOIs
StatePublished - Dec 1 2013

Fingerprint

Technetium Tc 99m Sestamibi
Syringes
Plastics
Adsorption
Lubricants
Injections
Clinical Studies
Quality Control

Keywords

  • Tc-sestamibi
  • Adhesion
  • Adsorption
  • plastic syringe

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Adsorption of 99mTc-sestamibi onto plastic syringes : Evaluation of factors affecting the degree of adsorption and their impact on clinical studies. / Swanson, Tiffinee N.; Troung, Duong T.; Paulsen, Andrew; Hruska, Carrie B; O'Connor, Michael K.

In: Journal of Nuclear Medicine Technology, Vol. 41, No. 4, 01.12.2013, p. 247-252.

Research output: Contribution to journalArticle

@article{ec31c26854924ce6bd30915498b8e1b7,
title = "Adsorption of 99mTc-sestamibi onto plastic syringes: Evaluation of factors affecting the degree of adsorption and their impact on clinical studies",
abstract = "The purpose of this study was to document the extent of adhesion of 99mTc-sestamibi to syringes in patient procedures,determine factors that influence the degree of adhesion, and evaluate alternatives to our current practice that would either result in a more reproducible degree of adhesion or, ideally, eliminate adhesion. Methods: The extent of adhesion was documented in 216 patient procedures and evaluated in detail in an additional 73 patient procedures. We evaluated the nature of the adhesion and its possible causes, including the location of adhesion in injection sets, the effect of syringe type, and the effect of prerinsing of syringes with various solutions of nonradiolabeled sestamibi and 99mTc-sestamibi. The extent of adhesion was reevaluated in 50 procedures performed using the syringe type that demonstrated the lowest adhesion rate. Results: The degree of adhesion of 99mTc-sestamibi to the injection set was found to be 20.1{\%} 6 8.0{\%}, with a range (10th- 90th percentiles) of 9{\%}-31{\%}. The primary cause of adhesion appeared to be the lubricant used inside the syringe barrel. Evaluation of 6 different syringe types identified a brand with a lower adhesion rate. Reevaluation in patient procedures using this brand showed a 5.2{\%} 6 2.5{\%} degree of adhesion, with a range (10th-90th percentiles) of 2.5{\%}-7.7{\%}. Conclusion: Selection of the appropriate type of syringe can significantly reduce the magnitude and variability of residual 99mTc-sestamibi activity. With more reproducible residual activities, we have been able to achieve an approximately 20{\%} reduction in the dispensed dose of 99mTc-sestamibi used in clinical procedures and a more consistent injected dose with less interpatient variation. The frequent changes in syringe design by manufacturers require that a quality control program for monitoring of residual activity be incorporated into clinical practice. This program has allowed us to maintain image quality and achieve more consistent injected patient doses in clinical procedures that use 99mTc-sestamibi.",
keywords = "Tc-sestamibi, Adhesion, Adsorption, plastic syringe",
author = "Swanson, {Tiffinee N.} and Troung, {Duong T.} and Andrew Paulsen and Hruska, {Carrie B} and O'Connor, {Michael K.}",
year = "2013",
month = "12",
day = "1",
doi = "10.2967/jnmt.113.132159",
language = "English (US)",
volume = "41",
pages = "247--252",
journal = "Journal of Nuclear Medicine Technology",
issn = "0091-4916",
publisher = "Society of Nuclear Medicine Inc.",
number = "4",

}

TY - JOUR

T1 - Adsorption of 99mTc-sestamibi onto plastic syringes

T2 - Evaluation of factors affecting the degree of adsorption and their impact on clinical studies

AU - Swanson, Tiffinee N.

AU - Troung, Duong T.

AU - Paulsen, Andrew

AU - Hruska, Carrie B

AU - O'Connor, Michael K.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - The purpose of this study was to document the extent of adhesion of 99mTc-sestamibi to syringes in patient procedures,determine factors that influence the degree of adhesion, and evaluate alternatives to our current practice that would either result in a more reproducible degree of adhesion or, ideally, eliminate adhesion. Methods: The extent of adhesion was documented in 216 patient procedures and evaluated in detail in an additional 73 patient procedures. We evaluated the nature of the adhesion and its possible causes, including the location of adhesion in injection sets, the effect of syringe type, and the effect of prerinsing of syringes with various solutions of nonradiolabeled sestamibi and 99mTc-sestamibi. The extent of adhesion was reevaluated in 50 procedures performed using the syringe type that demonstrated the lowest adhesion rate. Results: The degree of adhesion of 99mTc-sestamibi to the injection set was found to be 20.1% 6 8.0%, with a range (10th- 90th percentiles) of 9%-31%. The primary cause of adhesion appeared to be the lubricant used inside the syringe barrel. Evaluation of 6 different syringe types identified a brand with a lower adhesion rate. Reevaluation in patient procedures using this brand showed a 5.2% 6 2.5% degree of adhesion, with a range (10th-90th percentiles) of 2.5%-7.7%. Conclusion: Selection of the appropriate type of syringe can significantly reduce the magnitude and variability of residual 99mTc-sestamibi activity. With more reproducible residual activities, we have been able to achieve an approximately 20% reduction in the dispensed dose of 99mTc-sestamibi used in clinical procedures and a more consistent injected dose with less interpatient variation. The frequent changes in syringe design by manufacturers require that a quality control program for monitoring of residual activity be incorporated into clinical practice. This program has allowed us to maintain image quality and achieve more consistent injected patient doses in clinical procedures that use 99mTc-sestamibi.

AB - The purpose of this study was to document the extent of adhesion of 99mTc-sestamibi to syringes in patient procedures,determine factors that influence the degree of adhesion, and evaluate alternatives to our current practice that would either result in a more reproducible degree of adhesion or, ideally, eliminate adhesion. Methods: The extent of adhesion was documented in 216 patient procedures and evaluated in detail in an additional 73 patient procedures. We evaluated the nature of the adhesion and its possible causes, including the location of adhesion in injection sets, the effect of syringe type, and the effect of prerinsing of syringes with various solutions of nonradiolabeled sestamibi and 99mTc-sestamibi. The extent of adhesion was reevaluated in 50 procedures performed using the syringe type that demonstrated the lowest adhesion rate. Results: The degree of adhesion of 99mTc-sestamibi to the injection set was found to be 20.1% 6 8.0%, with a range (10th- 90th percentiles) of 9%-31%. The primary cause of adhesion appeared to be the lubricant used inside the syringe barrel. Evaluation of 6 different syringe types identified a brand with a lower adhesion rate. Reevaluation in patient procedures using this brand showed a 5.2% 6 2.5% degree of adhesion, with a range (10th-90th percentiles) of 2.5%-7.7%. Conclusion: Selection of the appropriate type of syringe can significantly reduce the magnitude and variability of residual 99mTc-sestamibi activity. With more reproducible residual activities, we have been able to achieve an approximately 20% reduction in the dispensed dose of 99mTc-sestamibi used in clinical procedures and a more consistent injected dose with less interpatient variation. The frequent changes in syringe design by manufacturers require that a quality control program for monitoring of residual activity be incorporated into clinical practice. This program has allowed us to maintain image quality and achieve more consistent injected patient doses in clinical procedures that use 99mTc-sestamibi.

KW - Tc-sestamibi

KW - Adhesion

KW - Adsorption

KW - plastic syringe

UR - http://www.scopus.com/inward/record.url?scp=84890876877&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890876877&partnerID=8YFLogxK

U2 - 10.2967/jnmt.113.132159

DO - 10.2967/jnmt.113.132159

M3 - Article

C2 - 24212450

AN - SCOPUS:84890876877

VL - 41

SP - 247

EP - 252

JO - Journal of Nuclear Medicine Technology

JF - Journal of Nuclear Medicine Technology

SN - 0091-4916

IS - 4

ER -