Adrenoleukodystrophy: Increased plasma content of saturated very long chain fatty acids

Hugo W. Moser, Ann B. Moser, Karen K. Frayer, Winston Chen, Joseph D. Schulman, Brian P. O’Neill, Yasuo Kishimoto

Research output: Contribution to journalArticle

296 Scopus citations

Abstract

With a new method we measured the saturated very long chain fatty acids in the plasma of adrenoleukodystrophy (ALD) hemizygotes, ALD heterozygotes, and controls. ALD hemizygotes showed increased levels of hexacosanoate (C26 fatty acid) which represented 0.081 ± 0.0066% (SEM) of total fatty acids, compared to 0.015 ± 0.0032% in the controls. C25, C24, and C23 fatty acids were also increased, but the C22 and C20 fatty acids were normal. C26 levels were also increased in most ALD heterozygotes, with a mean level 0.057 ± 0.0063% of total fatty acids. The technique can be used for diagnosis and carrier identification, and in the evaluation of therapy.

Original languageEnglish (US)
Pages (from-to)1241-1249
Number of pages9
JournalNeurology
Volume31
Issue number10
DOIs
StatePublished - Oct 1981

ASJC Scopus subject areas

  • Clinical Neurology

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    Moser, H. W., Moser, A. B., Frayer, K. K., Chen, W., Schulman, J. D., O’Neill, B. P., & Kishimoto, Y. (1981). Adrenoleukodystrophy: Increased plasma content of saturated very long chain fatty acids. Neurology, 31(10), 1241-1249. https://doi.org/10.1212/wnl.31.10.1241