Administration of Folium mori extract decreases nitric oxide synthase expression in the hypothalamus of streptozotocin-induced diabetic rats

Mi Hyeon Jang, Hong Kim, Min Chul Shin, Baek Vin Lim, Taeck Hyun Lee, Sae Bin Jung, Chang Ju Kim, Ee Hwa Kim

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Folium mori, the leaves of Morus alba L., has traditionally been used for the treatment of diabetic hyperglycemia. It has been shown to induce enhanced NOS expression in the hypothalamus of rats with streptozotocin (STZ)-induced diabetes. In the present study, the effect of Folium mori on the expression of nitric oxide synthase (NOS) in the hypothalamus of STZ-induced diabetic rats was investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Enhanced NAPDH-d expression was detected in the paraventricular nucleus, ventromedial hypothalamic nucleus, and lateral hypothalamic area of the hypothalamus in the STZ-induced diabetes group. Administration of the aqueous extract of Folium mori to rats with STZ-induced diabetes resulted in decreased NADPH-d positivity. These results suggest that Folium mori treatment is effective in curbing the desire for food under diabetic conditions via modulation of NO expression in the hypothalamus.

Original languageEnglish (US)
Pages (from-to)189-192
Number of pages4
JournalJapanese Journal of Pharmacology
Volume90
Issue number2
DOIs
StatePublished - Oct 1 2002

Keywords

  • Folium mori
  • Nitric oxide synthase
  • Streptozotocin-induced diabetes

ASJC Scopus subject areas

  • Pharmacology

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