Adherence to the Mediterranean diet during pregnancy and offspring adiposity and cardiometabolic traits in childhood

L. Chatzi, S. L. Rifas-Shiman, V. Georgiou, K. E. Joung, S. Koinaki, G. Chalkiadaki, A. Margioris, K. Sarri, Maria Vassilaki, M. Vafeiadi, M. Kogevinas, C. Mantzoros, M. W. Gillman, E. Oken

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: In adults, adherence to the Mediterranean diet has been inversely associated with cardiovascular risk, but the extent to which diet in pregnancy is associated with offspring adiposity is unclear. We aimed to investigate the association between adherence to Mediterranean diet in pregnancy and offspring cardiometabolic traits in two pregnancy cohorts. Methods: We studied 997 mother–child pairs from Project Viva in Massachusetts, USA, and 569 pairs from the Rhea study in Crete, Greece. We estimated adherence to the Mediterranean diet with an a priori defined score (MDS) of nine foods and nutrients (0 to 9). We measured child weight, height, waist circumference, skin-fold thicknesses, blood pressure, and blood levels of lipids, c-reactive protein and adipokines in mid-childhood (median 7.7 years) in Viva, and in early childhood (median 4.2 years) in Rhea. We calculated cohort-specific effects and pooled effects estimates with random-effects models for cohort and child age. Results: In Project Viva, the mean (SD, standard deviation) MDS was 2.7 (1.6); in Rhea it was 3.8 (1.7). In the pooled analysis, for each 3-point increment in the MDS, offspring BMI z-score was lower by 0.14 units (95% CI, −0.15 to −0.13), waist circumference by 0.39 cm (95% CI, −0.64 to −0.14), and the sum of skin-fold thicknesses by 0.63 mm (95% CI, −0.98 to −0.28). We also observed lower offspring systolic (−1.03 mmHg; 95% CI, −1.65 to −0.42) and diastolic blood pressure (−0.57 mmHg; 95% CI, −0.98 to −0.16). Conclusion: Greater adherence to Mediterranean diet during pregnancy may protect against excess offspring cardiometabolic risk.

Original languageEnglish (US)
Pages (from-to)47-56
Number of pages10
JournalPediatric obesity
Volume12
DOIs
StatePublished - Aug 1 2017
Externally publishedYes

Fingerprint

Mediterranean Diet
Rheiformes
Adiposity
Cohort Effect
Pregnancy
Greece
Waist Circumference
Blood Pressure
Food
Skin
Adipokines
Diet
Lipids
Weights and Measures
Proteins

Keywords

  • Blood pressure
  • cohort study
  • diet
  • lipids
  • obesity
  • pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Health Policy
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Chatzi, L., Rifas-Shiman, S. L., Georgiou, V., Joung, K. E., Koinaki, S., Chalkiadaki, G., ... Oken, E. (2017). Adherence to the Mediterranean diet during pregnancy and offspring adiposity and cardiometabolic traits in childhood. Pediatric obesity, 12, 47-56. https://doi.org/10.1111/ijpo.12191

Adherence to the Mediterranean diet during pregnancy and offspring adiposity and cardiometabolic traits in childhood. / Chatzi, L.; Rifas-Shiman, S. L.; Georgiou, V.; Joung, K. E.; Koinaki, S.; Chalkiadaki, G.; Margioris, A.; Sarri, K.; Vassilaki, Maria; Vafeiadi, M.; Kogevinas, M.; Mantzoros, C.; Gillman, M. W.; Oken, E.

In: Pediatric obesity, Vol. 12, 01.08.2017, p. 47-56.

Research output: Contribution to journalArticle

Chatzi, L, Rifas-Shiman, SL, Georgiou, V, Joung, KE, Koinaki, S, Chalkiadaki, G, Margioris, A, Sarri, K, Vassilaki, M, Vafeiadi, M, Kogevinas, M, Mantzoros, C, Gillman, MW & Oken, E 2017, 'Adherence to the Mediterranean diet during pregnancy and offspring adiposity and cardiometabolic traits in childhood', Pediatric obesity, vol. 12, pp. 47-56. https://doi.org/10.1111/ijpo.12191
Chatzi, L. ; Rifas-Shiman, S. L. ; Georgiou, V. ; Joung, K. E. ; Koinaki, S. ; Chalkiadaki, G. ; Margioris, A. ; Sarri, K. ; Vassilaki, Maria ; Vafeiadi, M. ; Kogevinas, M. ; Mantzoros, C. ; Gillman, M. W. ; Oken, E. / Adherence to the Mediterranean diet during pregnancy and offspring adiposity and cardiometabolic traits in childhood. In: Pediatric obesity. 2017 ; Vol. 12. pp. 47-56.
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abstract = "Background: In adults, adherence to the Mediterranean diet has been inversely associated with cardiovascular risk, but the extent to which diet in pregnancy is associated with offspring adiposity is unclear. We aimed to investigate the association between adherence to Mediterranean diet in pregnancy and offspring cardiometabolic traits in two pregnancy cohorts. Methods: We studied 997 mother–child pairs from Project Viva in Massachusetts, USA, and 569 pairs from the Rhea study in Crete, Greece. We estimated adherence to the Mediterranean diet with an a priori defined score (MDS) of nine foods and nutrients (0 to 9). We measured child weight, height, waist circumference, skin-fold thicknesses, blood pressure, and blood levels of lipids, c-reactive protein and adipokines in mid-childhood (median 7.7 years) in Viva, and in early childhood (median 4.2 years) in Rhea. We calculated cohort-specific effects and pooled effects estimates with random-effects models for cohort and child age. Results: In Project Viva, the mean (SD, standard deviation) MDS was 2.7 (1.6); in Rhea it was 3.8 (1.7). In the pooled analysis, for each 3-point increment in the MDS, offspring BMI z-score was lower by 0.14 units (95{\%} CI, −0.15 to −0.13), waist circumference by 0.39 cm (95{\%} CI, −0.64 to −0.14), and the sum of skin-fold thicknesses by 0.63 mm (95{\%} CI, −0.98 to −0.28). We also observed lower offspring systolic (−1.03 mmHg; 95{\%} CI, −1.65 to −0.42) and diastolic blood pressure (−0.57 mmHg; 95{\%} CI, −0.98 to −0.16). Conclusion: Greater adherence to Mediterranean diet during pregnancy may protect against excess offspring cardiometabolic risk.",
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AU - Joung, K. E.

AU - Koinaki, S.

AU - Chalkiadaki, G.

AU - Margioris, A.

AU - Sarri, K.

AU - Vassilaki, Maria

AU - Vafeiadi, M.

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