Adenovirus-induced interstitial nephritis following umbilical cord blood transplant for chronic lymphocytic leukemia

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10 Citations (Scopus)

Abstract

We present a case of a 27-year-old man who received an unrelated donor umbilical cord blood transplant for chronic lymphocytic leukemia. His postsurgery course was complicated by acute kidney injury, hemorrhagic cystitis, and pancytopenia. Transjugular kidney biopsy showed interstitial nephritis. Viral inclusions were present in tubular epithelial cells, and in situ hybridization studies confirmed the presence of adenovirus. Kidney function improved after a short course of cidofovir. Adenovirus-induced interstitial nephritis should be considered in the differential diagnosis in all cases of interstitial nephritis occurring in immunocompromised patients.

Original languageEnglish (US)
Pages (from-to)886-890
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume59
Issue number6
DOIs
StatePublished - Jun 2012

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Interstitial Nephritis
B-Cell Chronic Lymphocytic Leukemia
Fetal Blood
Adenoviridae
Transplants
Kidney
Unrelated Donors
Pancytopenia
Cystitis
Immunocompromised Host
Acute Kidney Injury
In Situ Hybridization
Differential Diagnosis
Epithelial Cells
Biopsy

Keywords

  • adenovirus
  • Granulomatous interstitial nephritis
  • umbilical cord blood transplant

ASJC Scopus subject areas

  • Nephrology

Cite this

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abstract = "We present a case of a 27-year-old man who received an unrelated donor umbilical cord blood transplant for chronic lymphocytic leukemia. His postsurgery course was complicated by acute kidney injury, hemorrhagic cystitis, and pancytopenia. Transjugular kidney biopsy showed interstitial nephritis. Viral inclusions were present in tubular epithelial cells, and in situ hybridization studies confirmed the presence of adenovirus. Kidney function improved after a short course of cidofovir. Adenovirus-induced interstitial nephritis should be considered in the differential diagnosis in all cases of interstitial nephritis occurring in immunocompromised patients.",
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AB - We present a case of a 27-year-old man who received an unrelated donor umbilical cord blood transplant for chronic lymphocytic leukemia. His postsurgery course was complicated by acute kidney injury, hemorrhagic cystitis, and pancytopenia. Transjugular kidney biopsy showed interstitial nephritis. Viral inclusions were present in tubular epithelial cells, and in situ hybridization studies confirmed the presence of adenovirus. Kidney function improved after a short course of cidofovir. Adenovirus-induced interstitial nephritis should be considered in the differential diagnosis in all cases of interstitial nephritis occurring in immunocompromised patients.

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